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microRNAs Orchestrate Pathophysiology of Breast Cancer Brain Metastasis: Advances in Therapy
Brain metastasis (BM) predominantly occurs in triple-negative (TN) and epidermal growth factor 2 (HER2)-positive breast cancer (BC) patients, and currently, there is an unmet need for the treatment of these patients. BM is a complex process that is regulated by the formation of a metastatic niche. A...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7023699/ https://www.ncbi.nlm.nih.gov/pubmed/32059676 http://dx.doi.org/10.1186/s12943-020-1140-x |
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author | Kanchan, Ranjana K. Siddiqui, Jawed A. Mahapatra, Sidharth Batra, Surinder K. Nasser, Mohd W. |
author_facet | Kanchan, Ranjana K. Siddiqui, Jawed A. Mahapatra, Sidharth Batra, Surinder K. Nasser, Mohd W. |
author_sort | Kanchan, Ranjana K. |
collection | PubMed |
description | Brain metastasis (BM) predominantly occurs in triple-negative (TN) and epidermal growth factor 2 (HER2)-positive breast cancer (BC) patients, and currently, there is an unmet need for the treatment of these patients. BM is a complex process that is regulated by the formation of a metastatic niche. A better understanding of the brain metastatic processes and the crosstalk between cancer cells and brain microenvironment is essential for designing a novel therapeutic approach. In this context, the aberrant expression of miRNA has been shown to be associated with BM. These non-coding RNAs/miRNAs regulate metastasis through modulating the formation of a metastatic niche and metabolic reprogramming via regulation of their target genes. However, the role of miRNA in breast cancer brain metastasis (BCBM) is poorly explored. Thus, identification and understanding of miRNAs in the pathobiology of BCBM may identify a novel candidate miRNA for the early diagnosis and prevention of this devastating process. In this review, we focus on understanding the role of candidate miRNAs in the regulation of BC brain metastatic processes as well as designing novel miRNA-based therapeutic strategies for BCBM. |
format | Online Article Text |
id | pubmed-7023699 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-70236992020-02-20 microRNAs Orchestrate Pathophysiology of Breast Cancer Brain Metastasis: Advances in Therapy Kanchan, Ranjana K. Siddiqui, Jawed A. Mahapatra, Sidharth Batra, Surinder K. Nasser, Mohd W. Mol Cancer Review Brain metastasis (BM) predominantly occurs in triple-negative (TN) and epidermal growth factor 2 (HER2)-positive breast cancer (BC) patients, and currently, there is an unmet need for the treatment of these patients. BM is a complex process that is regulated by the formation of a metastatic niche. A better understanding of the brain metastatic processes and the crosstalk between cancer cells and brain microenvironment is essential for designing a novel therapeutic approach. In this context, the aberrant expression of miRNA has been shown to be associated with BM. These non-coding RNAs/miRNAs regulate metastasis through modulating the formation of a metastatic niche and metabolic reprogramming via regulation of their target genes. However, the role of miRNA in breast cancer brain metastasis (BCBM) is poorly explored. Thus, identification and understanding of miRNAs in the pathobiology of BCBM may identify a novel candidate miRNA for the early diagnosis and prevention of this devastating process. In this review, we focus on understanding the role of candidate miRNAs in the regulation of BC brain metastatic processes as well as designing novel miRNA-based therapeutic strategies for BCBM. BioMed Central 2020-02-15 /pmc/articles/PMC7023699/ /pubmed/32059676 http://dx.doi.org/10.1186/s12943-020-1140-x Text en © The Author(s). 2020 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Review Kanchan, Ranjana K. Siddiqui, Jawed A. Mahapatra, Sidharth Batra, Surinder K. Nasser, Mohd W. microRNAs Orchestrate Pathophysiology of Breast Cancer Brain Metastasis: Advances in Therapy |
title | microRNAs Orchestrate Pathophysiology of Breast Cancer Brain Metastasis: Advances in Therapy |
title_full | microRNAs Orchestrate Pathophysiology of Breast Cancer Brain Metastasis: Advances in Therapy |
title_fullStr | microRNAs Orchestrate Pathophysiology of Breast Cancer Brain Metastasis: Advances in Therapy |
title_full_unstemmed | microRNAs Orchestrate Pathophysiology of Breast Cancer Brain Metastasis: Advances in Therapy |
title_short | microRNAs Orchestrate Pathophysiology of Breast Cancer Brain Metastasis: Advances in Therapy |
title_sort | micrornas orchestrate pathophysiology of breast cancer brain metastasis: advances in therapy |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7023699/ https://www.ncbi.nlm.nih.gov/pubmed/32059676 http://dx.doi.org/10.1186/s12943-020-1140-x |
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