Cargando…
Rat Chondrocyte Inflammation and Osteoarthritis Are Ameliorated by Madecassoside
As a joint disease, osteoarthritis (OA) is caused by the breakdown of subchondral bone and cartilage damage. Inflammatory factors, such as interleukin- (IL-) 1β, mediate the progression of OA. Madecassoside (MA), a triterpenoid component derived from the gotu kola herb (Centella asiatica), exhibits...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7023724/ https://www.ncbi.nlm.nih.gov/pubmed/32089778 http://dx.doi.org/10.1155/2020/7540197 |
_version_ | 1783498312849031168 |
---|---|
author | Moqbel, Safwat Adel Abdo He, Yuzhe Xu, Langhai Ma, Chiyuan Ran, Jisheng Xu, Kai Wu, Lidong |
author_facet | Moqbel, Safwat Adel Abdo He, Yuzhe Xu, Langhai Ma, Chiyuan Ran, Jisheng Xu, Kai Wu, Lidong |
author_sort | Moqbel, Safwat Adel Abdo |
collection | PubMed |
description | As a joint disease, osteoarthritis (OA) is caused by the breakdown of subchondral bone and cartilage damage. Inflammatory factors, such as interleukin- (IL-) 1β, mediate the progression of OA. Madecassoside (MA), a triterpenoid component derived from the gotu kola herb (Centella asiatica), exhibits various pharmacological effects, including antioxidative and anti-inflammatory properties. In the present study, the protective effects and possible mechanism of MA on the treatment of OA were investigated. MA was demonstrated to significantly suppress the IL-1β-induced overexpression of matrix metalloproteinase- (MMP-) 3, MMP-13, inducible nitric oxide synthase (iNOS), and cyclooxygenase-2 (COX-2) and to decrease the IL-1β-induced degradation of type II collagen and sox9. Additionally, MA was able to reduce the IL-1β-induced phosphorylation of p65 in osteoarthritic chondrocytes. Furthermore, in a rat OA model, MA prevented cartilage degeneration and reduced the OARSI score in the MA-treated group compared with the OA group. The present study showed that MA suppresses the nuclear factor-κB signaling pathway, reducing IL-1β-induced chondrocyte inflammation, which indicates the therapeutic potential of MA in patients with OA. |
format | Online Article Text |
id | pubmed-7023724 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-70237242020-02-22 Rat Chondrocyte Inflammation and Osteoarthritis Are Ameliorated by Madecassoside Moqbel, Safwat Adel Abdo He, Yuzhe Xu, Langhai Ma, Chiyuan Ran, Jisheng Xu, Kai Wu, Lidong Oxid Med Cell Longev Research Article As a joint disease, osteoarthritis (OA) is caused by the breakdown of subchondral bone and cartilage damage. Inflammatory factors, such as interleukin- (IL-) 1β, mediate the progression of OA. Madecassoside (MA), a triterpenoid component derived from the gotu kola herb (Centella asiatica), exhibits various pharmacological effects, including antioxidative and anti-inflammatory properties. In the present study, the protective effects and possible mechanism of MA on the treatment of OA were investigated. MA was demonstrated to significantly suppress the IL-1β-induced overexpression of matrix metalloproteinase- (MMP-) 3, MMP-13, inducible nitric oxide synthase (iNOS), and cyclooxygenase-2 (COX-2) and to decrease the IL-1β-induced degradation of type II collagen and sox9. Additionally, MA was able to reduce the IL-1β-induced phosphorylation of p65 in osteoarthritic chondrocytes. Furthermore, in a rat OA model, MA prevented cartilage degeneration and reduced the OARSI score in the MA-treated group compared with the OA group. The present study showed that MA suppresses the nuclear factor-κB signaling pathway, reducing IL-1β-induced chondrocyte inflammation, which indicates the therapeutic potential of MA in patients with OA. Hindawi 2020-02-01 /pmc/articles/PMC7023724/ /pubmed/32089778 http://dx.doi.org/10.1155/2020/7540197 Text en Copyright © 2020 Safwat Adel Abdo Moqbel et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Moqbel, Safwat Adel Abdo He, Yuzhe Xu, Langhai Ma, Chiyuan Ran, Jisheng Xu, Kai Wu, Lidong Rat Chondrocyte Inflammation and Osteoarthritis Are Ameliorated by Madecassoside |
title | Rat Chondrocyte Inflammation and Osteoarthritis Are Ameliorated by Madecassoside |
title_full | Rat Chondrocyte Inflammation and Osteoarthritis Are Ameliorated by Madecassoside |
title_fullStr | Rat Chondrocyte Inflammation and Osteoarthritis Are Ameliorated by Madecassoside |
title_full_unstemmed | Rat Chondrocyte Inflammation and Osteoarthritis Are Ameliorated by Madecassoside |
title_short | Rat Chondrocyte Inflammation and Osteoarthritis Are Ameliorated by Madecassoside |
title_sort | rat chondrocyte inflammation and osteoarthritis are ameliorated by madecassoside |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7023724/ https://www.ncbi.nlm.nih.gov/pubmed/32089778 http://dx.doi.org/10.1155/2020/7540197 |
work_keys_str_mv | AT moqbelsafwatadelabdo ratchondrocyteinflammationandosteoarthritisareamelioratedbymadecassoside AT heyuzhe ratchondrocyteinflammationandosteoarthritisareamelioratedbymadecassoside AT xulanghai ratchondrocyteinflammationandosteoarthritisareamelioratedbymadecassoside AT machiyuan ratchondrocyteinflammationandosteoarthritisareamelioratedbymadecassoside AT ranjisheng ratchondrocyteinflammationandosteoarthritisareamelioratedbymadecassoside AT xukai ratchondrocyteinflammationandosteoarthritisareamelioratedbymadecassoside AT wulidong ratchondrocyteinflammationandosteoarthritisareamelioratedbymadecassoside |