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Modification of PMMA Cements for Cranioplasty with Bioactive Glass and Copper Doped Tricalcium Phosphate Particles

Cranioplasty represents the surgical repair of bone defects or deformities in the cranium arising from traumatic skull bone fracture, cranial bone deformities, bone cancer, and infections. The actual gold standard in surgery procedures for cranioplasty involves the use of biocompatible materials, an...

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Detalles Bibliográficos
Autores principales: Russo, Teresa, De Santis, Roberto, Gloria, Antonio, Barbaro, Katia, Altigeri, Annalisa, Fadeeva, Inna V., Rau, Julietta V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7023726/
https://www.ncbi.nlm.nih.gov/pubmed/31881672
http://dx.doi.org/10.3390/polym12010037
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author Russo, Teresa
De Santis, Roberto
Gloria, Antonio
Barbaro, Katia
Altigeri, Annalisa
Fadeeva, Inna V.
Rau, Julietta V.
author_facet Russo, Teresa
De Santis, Roberto
Gloria, Antonio
Barbaro, Katia
Altigeri, Annalisa
Fadeeva, Inna V.
Rau, Julietta V.
author_sort Russo, Teresa
collection PubMed
description Cranioplasty represents the surgical repair of bone defects or deformities in the cranium arising from traumatic skull bone fracture, cranial bone deformities, bone cancer, and infections. The actual gold standard in surgery procedures for cranioplasty involves the use of biocompatible materials, and repair or regeneration of large cranial defects is particularly challenging from both a functional and aesthetic point of view. PMMA-based bone cement are the most widely biomaterials adopted in the field, with at least four different surgical approaches. Modifications for improving biological and mechanical functions of PMMA-based bone cement have been suggested. To this aim, the inclusion of antibiotics to prevent infection has been shown to provide a reduction of mechanical properties in bending. Therefore, the development of novel antibacterial active agents to overcome issues related to mechanical properties and bacterial resistance to antibiotics is still encouraged. In this context, mechanical, biological, and antibacterial feature against P. aeruginosa and S. aureus bacterial strains of surgical PMMA cement modified with BG and recently developed Cu-TCP bioactive particles have been highlighted.
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spelling pubmed-70237262020-03-11 Modification of PMMA Cements for Cranioplasty with Bioactive Glass and Copper Doped Tricalcium Phosphate Particles Russo, Teresa De Santis, Roberto Gloria, Antonio Barbaro, Katia Altigeri, Annalisa Fadeeva, Inna V. Rau, Julietta V. Polymers (Basel) Article Cranioplasty represents the surgical repair of bone defects or deformities in the cranium arising from traumatic skull bone fracture, cranial bone deformities, bone cancer, and infections. The actual gold standard in surgery procedures for cranioplasty involves the use of biocompatible materials, and repair or regeneration of large cranial defects is particularly challenging from both a functional and aesthetic point of view. PMMA-based bone cement are the most widely biomaterials adopted in the field, with at least four different surgical approaches. Modifications for improving biological and mechanical functions of PMMA-based bone cement have been suggested. To this aim, the inclusion of antibiotics to prevent infection has been shown to provide a reduction of mechanical properties in bending. Therefore, the development of novel antibacterial active agents to overcome issues related to mechanical properties and bacterial resistance to antibiotics is still encouraged. In this context, mechanical, biological, and antibacterial feature against P. aeruginosa and S. aureus bacterial strains of surgical PMMA cement modified with BG and recently developed Cu-TCP bioactive particles have been highlighted. MDPI 2019-12-25 /pmc/articles/PMC7023726/ /pubmed/31881672 http://dx.doi.org/10.3390/polym12010037 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Russo, Teresa
De Santis, Roberto
Gloria, Antonio
Barbaro, Katia
Altigeri, Annalisa
Fadeeva, Inna V.
Rau, Julietta V.
Modification of PMMA Cements for Cranioplasty with Bioactive Glass and Copper Doped Tricalcium Phosphate Particles
title Modification of PMMA Cements for Cranioplasty with Bioactive Glass and Copper Doped Tricalcium Phosphate Particles
title_full Modification of PMMA Cements for Cranioplasty with Bioactive Glass and Copper Doped Tricalcium Phosphate Particles
title_fullStr Modification of PMMA Cements for Cranioplasty with Bioactive Glass and Copper Doped Tricalcium Phosphate Particles
title_full_unstemmed Modification of PMMA Cements for Cranioplasty with Bioactive Glass and Copper Doped Tricalcium Phosphate Particles
title_short Modification of PMMA Cements for Cranioplasty with Bioactive Glass and Copper Doped Tricalcium Phosphate Particles
title_sort modification of pmma cements for cranioplasty with bioactive glass and copper doped tricalcium phosphate particles
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7023726/
https://www.ncbi.nlm.nih.gov/pubmed/31881672
http://dx.doi.org/10.3390/polym12010037
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