Clemastine improves hypomyelination in rats with hypoxic–ischemic brain injury by reducing microglia-derived IL-1β via P38 signaling pathway

BACKGROUND: Microglia activation is associated with the development of hypoxic–ischemic brain injury (HIBI). Neuroinflammation suppression might be a suitable therapeutic target in hypoxic oligodendrocyte injury. This study aims to determine whether clemastine can improve hypomyelination by suppress...

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Detalles Bibliográficos
Autores principales: Xie, Di, Ge, Xiaoli, Ma, Yanli, Tang, Jialong, Wang, Yang, Zhu, Yajie, Gao, Chengjin, Pan, Shuming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7023767/
https://www.ncbi.nlm.nih.gov/pubmed/32061255
http://dx.doi.org/10.1186/s12974-019-1662-6

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