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The Safety and Exploration of the Pharmacokinetics of Intrapleural Liposomal Curcumin
BACKGROUND: Malignant pleural effusion (MPE) is the accumulation of fluid in the pleural cavity as a result of malignancies affecting the lung, pleura and mediastinal lymph nodes. Curcumin, a compound found in turmeric, has anti-cancer properties that could not only treat MPE accumulation but also r...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7023862/ https://www.ncbi.nlm.nih.gov/pubmed/32103948 http://dx.doi.org/10.2147/IJN.S237536 |
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author | Hocking, Ashleigh Tommasi, Sara Sordillo, Peter Klebe, Sonja |
author_facet | Hocking, Ashleigh Tommasi, Sara Sordillo, Peter Klebe, Sonja |
author_sort | Hocking, Ashleigh |
collection | PubMed |
description | BACKGROUND: Malignant pleural effusion (MPE) is the accumulation of fluid in the pleural cavity as a result of malignancies affecting the lung, pleura and mediastinal lymph nodes. Curcumin, a compound found in turmeric, has anti-cancer properties that could not only treat MPE accumulation but also reduce cancer burden. To our knowledge, direct administration of curcumin into the pleural cavity has never been reported, neither in animals nor in humans. PURPOSE: To explore the compartmental distribution, targeted pharmacokinetics and the safety profile of liposomal curcumin following intrapleural and intravenous administration. METHODS: Liposomal curcumin (16 mg/kg) was administered into Fischer 344 rats by either intrapleural injection or intravenous infusion. The concentration of curcumin in plasma and tissues (lung, liver and diaphragm) were measured using ultra-performance liquid chromatography-mass spectrometry (UPLC-MS). Blood and tissues were examined for pathological changes. RESULTS: No pleural or lung pathologies were observed following intrapleural liposomal curcumin administration. Total curcumin concentration peaked 1.5 hrs after the administration of intrapleural liposomal curcumin and red blood cell morphology appeared normal. A red blood cells abnormality (echinocytosis) was observed immediately and at 1.5 hrs after intravenous infusion of liposomal curcumin. CONCLUSION: These results indicate that liposomal curcumin is safe when administered directly into the pleural cavity and may represent a viable alternative to intravenous infusion in patients with pleural-based tumors. |
format | Online Article Text |
id | pubmed-7023862 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Dove |
record_format | MEDLINE/PubMed |
spelling | pubmed-70238622020-02-26 The Safety and Exploration of the Pharmacokinetics of Intrapleural Liposomal Curcumin Hocking, Ashleigh Tommasi, Sara Sordillo, Peter Klebe, Sonja Int J Nanomedicine Original Research BACKGROUND: Malignant pleural effusion (MPE) is the accumulation of fluid in the pleural cavity as a result of malignancies affecting the lung, pleura and mediastinal lymph nodes. Curcumin, a compound found in turmeric, has anti-cancer properties that could not only treat MPE accumulation but also reduce cancer burden. To our knowledge, direct administration of curcumin into the pleural cavity has never been reported, neither in animals nor in humans. PURPOSE: To explore the compartmental distribution, targeted pharmacokinetics and the safety profile of liposomal curcumin following intrapleural and intravenous administration. METHODS: Liposomal curcumin (16 mg/kg) was administered into Fischer 344 rats by either intrapleural injection or intravenous infusion. The concentration of curcumin in plasma and tissues (lung, liver and diaphragm) were measured using ultra-performance liquid chromatography-mass spectrometry (UPLC-MS). Blood and tissues were examined for pathological changes. RESULTS: No pleural or lung pathologies were observed following intrapleural liposomal curcumin administration. Total curcumin concentration peaked 1.5 hrs after the administration of intrapleural liposomal curcumin and red blood cell morphology appeared normal. A red blood cells abnormality (echinocytosis) was observed immediately and at 1.5 hrs after intravenous infusion of liposomal curcumin. CONCLUSION: These results indicate that liposomal curcumin is safe when administered directly into the pleural cavity and may represent a viable alternative to intravenous infusion in patients with pleural-based tumors. Dove 2020-02-11 /pmc/articles/PMC7023862/ /pubmed/32103948 http://dx.doi.org/10.2147/IJN.S237536 Text en © 2020 Hocking et al. http://creativecommons.org/licenses/by-nc/3.0/ This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php). |
spellingShingle | Original Research Hocking, Ashleigh Tommasi, Sara Sordillo, Peter Klebe, Sonja The Safety and Exploration of the Pharmacokinetics of Intrapleural Liposomal Curcumin |
title | The Safety and Exploration of the Pharmacokinetics of Intrapleural Liposomal Curcumin |
title_full | The Safety and Exploration of the Pharmacokinetics of Intrapleural Liposomal Curcumin |
title_fullStr | The Safety and Exploration of the Pharmacokinetics of Intrapleural Liposomal Curcumin |
title_full_unstemmed | The Safety and Exploration of the Pharmacokinetics of Intrapleural Liposomal Curcumin |
title_short | The Safety and Exploration of the Pharmacokinetics of Intrapleural Liposomal Curcumin |
title_sort | safety and exploration of the pharmacokinetics of intrapleural liposomal curcumin |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7023862/ https://www.ncbi.nlm.nih.gov/pubmed/32103948 http://dx.doi.org/10.2147/IJN.S237536 |
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