Cargando…

The Safety and Exploration of the Pharmacokinetics of Intrapleural Liposomal Curcumin

BACKGROUND: Malignant pleural effusion (MPE) is the accumulation of fluid in the pleural cavity as a result of malignancies affecting the lung, pleura and mediastinal lymph nodes. Curcumin, a compound found in turmeric, has anti-cancer properties that could not only treat MPE accumulation but also r...

Descripción completa

Detalles Bibliográficos
Autores principales: Hocking, Ashleigh, Tommasi, Sara, Sordillo, Peter, Klebe, Sonja
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7023862/
https://www.ncbi.nlm.nih.gov/pubmed/32103948
http://dx.doi.org/10.2147/IJN.S237536
_version_ 1783498345014099968
author Hocking, Ashleigh
Tommasi, Sara
Sordillo, Peter
Klebe, Sonja
author_facet Hocking, Ashleigh
Tommasi, Sara
Sordillo, Peter
Klebe, Sonja
author_sort Hocking, Ashleigh
collection PubMed
description BACKGROUND: Malignant pleural effusion (MPE) is the accumulation of fluid in the pleural cavity as a result of malignancies affecting the lung, pleura and mediastinal lymph nodes. Curcumin, a compound found in turmeric, has anti-cancer properties that could not only treat MPE accumulation but also reduce cancer burden. To our knowledge, direct administration of curcumin into the pleural cavity has never been reported, neither in animals nor in humans. PURPOSE: To explore the compartmental distribution, targeted pharmacokinetics and the safety profile of liposomal curcumin following intrapleural and intravenous administration. METHODS: Liposomal curcumin (16 mg/kg) was administered into Fischer 344 rats by either intrapleural injection or intravenous infusion. The concentration of curcumin in plasma and tissues (lung, liver and diaphragm) were measured using ultra-performance liquid chromatography-mass spectrometry (UPLC-MS). Blood and tissues were examined for pathological changes. RESULTS: No pleural or lung pathologies were observed following intrapleural liposomal curcumin administration. Total curcumin concentration peaked 1.5 hrs after the administration of intrapleural liposomal curcumin and red blood cell morphology appeared normal. A red blood cells abnormality (echinocytosis) was observed immediately and at 1.5 hrs after intravenous infusion of liposomal curcumin. CONCLUSION: These results indicate that liposomal curcumin is safe when administered directly into the pleural cavity and may represent a viable alternative to intravenous infusion in patients with pleural-based tumors.
format Online
Article
Text
id pubmed-7023862
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Dove
record_format MEDLINE/PubMed
spelling pubmed-70238622020-02-26 The Safety and Exploration of the Pharmacokinetics of Intrapleural Liposomal Curcumin Hocking, Ashleigh Tommasi, Sara Sordillo, Peter Klebe, Sonja Int J Nanomedicine Original Research BACKGROUND: Malignant pleural effusion (MPE) is the accumulation of fluid in the pleural cavity as a result of malignancies affecting the lung, pleura and mediastinal lymph nodes. Curcumin, a compound found in turmeric, has anti-cancer properties that could not only treat MPE accumulation but also reduce cancer burden. To our knowledge, direct administration of curcumin into the pleural cavity has never been reported, neither in animals nor in humans. PURPOSE: To explore the compartmental distribution, targeted pharmacokinetics and the safety profile of liposomal curcumin following intrapleural and intravenous administration. METHODS: Liposomal curcumin (16 mg/kg) was administered into Fischer 344 rats by either intrapleural injection or intravenous infusion. The concentration of curcumin in plasma and tissues (lung, liver and diaphragm) were measured using ultra-performance liquid chromatography-mass spectrometry (UPLC-MS). Blood and tissues were examined for pathological changes. RESULTS: No pleural or lung pathologies were observed following intrapleural liposomal curcumin administration. Total curcumin concentration peaked 1.5 hrs after the administration of intrapleural liposomal curcumin and red blood cell morphology appeared normal. A red blood cells abnormality (echinocytosis) was observed immediately and at 1.5 hrs after intravenous infusion of liposomal curcumin. CONCLUSION: These results indicate that liposomal curcumin is safe when administered directly into the pleural cavity and may represent a viable alternative to intravenous infusion in patients with pleural-based tumors. Dove 2020-02-11 /pmc/articles/PMC7023862/ /pubmed/32103948 http://dx.doi.org/10.2147/IJN.S237536 Text en © 2020 Hocking et al. http://creativecommons.org/licenses/by-nc/3.0/ This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Original Research
Hocking, Ashleigh
Tommasi, Sara
Sordillo, Peter
Klebe, Sonja
The Safety and Exploration of the Pharmacokinetics of Intrapleural Liposomal Curcumin
title The Safety and Exploration of the Pharmacokinetics of Intrapleural Liposomal Curcumin
title_full The Safety and Exploration of the Pharmacokinetics of Intrapleural Liposomal Curcumin
title_fullStr The Safety and Exploration of the Pharmacokinetics of Intrapleural Liposomal Curcumin
title_full_unstemmed The Safety and Exploration of the Pharmacokinetics of Intrapleural Liposomal Curcumin
title_short The Safety and Exploration of the Pharmacokinetics of Intrapleural Liposomal Curcumin
title_sort safety and exploration of the pharmacokinetics of intrapleural liposomal curcumin
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7023862/
https://www.ncbi.nlm.nih.gov/pubmed/32103948
http://dx.doi.org/10.2147/IJN.S237536
work_keys_str_mv AT hockingashleigh thesafetyandexplorationofthepharmacokineticsofintrapleuralliposomalcurcumin
AT tommasisara thesafetyandexplorationofthepharmacokineticsofintrapleuralliposomalcurcumin
AT sordillopeter thesafetyandexplorationofthepharmacokineticsofintrapleuralliposomalcurcumin
AT klebesonja thesafetyandexplorationofthepharmacokineticsofintrapleuralliposomalcurcumin
AT hockingashleigh safetyandexplorationofthepharmacokineticsofintrapleuralliposomalcurcumin
AT tommasisara safetyandexplorationofthepharmacokineticsofintrapleuralliposomalcurcumin
AT sordillopeter safetyandexplorationofthepharmacokineticsofintrapleuralliposomalcurcumin
AT klebesonja safetyandexplorationofthepharmacokineticsofintrapleuralliposomalcurcumin