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Multifaceted Roles of TAK1 Signaling in Cancer
Context-specific signaling is a prevalent theme in cancer biology wherein individual molecules and pathways can have multiple or even opposite effects depending on the tumor type. TAK1 represents a particularly notable example of such signaling diversity in cancer progression. Originally discovered...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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2019
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7023988/ https://www.ncbi.nlm.nih.gov/pubmed/31695153 http://dx.doi.org/10.1038/s41388-019-1088-8 |
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author | Mukhopadhyay, Himadri Lee, Nam Y. |
author_facet | Mukhopadhyay, Himadri Lee, Nam Y. |
author_sort | Mukhopadhyay, Himadri |
collection | PubMed |
description | Context-specific signaling is a prevalent theme in cancer biology wherein individual molecules and pathways can have multiple or even opposite effects depending on the tumor type. TAK1 represents a particularly notable example of such signaling diversity in cancer progression. Originally discovered as a TGF-β-activated kinase, over the years it has been shown to respond to numerous other stimuli to phosphorylate a wide range of downstream targets and elicit distinct cellular responses across cell and tissue types. Here we present a comprehensive review of TAK1 signaling and provide important therapeutic perspectives related to its function in different cancers. |
format | Online Article Text |
id | pubmed-7023988 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
record_format | MEDLINE/PubMed |
spelling | pubmed-70239882020-05-06 Multifaceted Roles of TAK1 Signaling in Cancer Mukhopadhyay, Himadri Lee, Nam Y. Oncogene Article Context-specific signaling is a prevalent theme in cancer biology wherein individual molecules and pathways can have multiple or even opposite effects depending on the tumor type. TAK1 represents a particularly notable example of such signaling diversity in cancer progression. Originally discovered as a TGF-β-activated kinase, over the years it has been shown to respond to numerous other stimuli to phosphorylate a wide range of downstream targets and elicit distinct cellular responses across cell and tissue types. Here we present a comprehensive review of TAK1 signaling and provide important therapeutic perspectives related to its function in different cancers. 2019-11-06 2020-02 /pmc/articles/PMC7023988/ /pubmed/31695153 http://dx.doi.org/10.1038/s41388-019-1088-8 Text en Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms |
spellingShingle | Article Mukhopadhyay, Himadri Lee, Nam Y. Multifaceted Roles of TAK1 Signaling in Cancer |
title | Multifaceted Roles of TAK1 Signaling in Cancer |
title_full | Multifaceted Roles of TAK1 Signaling in Cancer |
title_fullStr | Multifaceted Roles of TAK1 Signaling in Cancer |
title_full_unstemmed | Multifaceted Roles of TAK1 Signaling in Cancer |
title_short | Multifaceted Roles of TAK1 Signaling in Cancer |
title_sort | multifaceted roles of tak1 signaling in cancer |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7023988/ https://www.ncbi.nlm.nih.gov/pubmed/31695153 http://dx.doi.org/10.1038/s41388-019-1088-8 |
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