Cargando…

Multifaceted Roles of TAK1 Signaling in Cancer

Context-specific signaling is a prevalent theme in cancer biology wherein individual molecules and pathways can have multiple or even opposite effects depending on the tumor type. TAK1 represents a particularly notable example of such signaling diversity in cancer progression. Originally discovered...

Descripción completa

Detalles Bibliográficos
Autores principales: Mukhopadhyay, Himadri, Lee, Nam Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7023988/
https://www.ncbi.nlm.nih.gov/pubmed/31695153
http://dx.doi.org/10.1038/s41388-019-1088-8
_version_ 1783498355031146496
author Mukhopadhyay, Himadri
Lee, Nam Y.
author_facet Mukhopadhyay, Himadri
Lee, Nam Y.
author_sort Mukhopadhyay, Himadri
collection PubMed
description Context-specific signaling is a prevalent theme in cancer biology wherein individual molecules and pathways can have multiple or even opposite effects depending on the tumor type. TAK1 represents a particularly notable example of such signaling diversity in cancer progression. Originally discovered as a TGF-β-activated kinase, over the years it has been shown to respond to numerous other stimuli to phosphorylate a wide range of downstream targets and elicit distinct cellular responses across cell and tissue types. Here we present a comprehensive review of TAK1 signaling and provide important therapeutic perspectives related to its function in different cancers.
format Online
Article
Text
id pubmed-7023988
institution National Center for Biotechnology Information
language English
publishDate 2019
record_format MEDLINE/PubMed
spelling pubmed-70239882020-05-06 Multifaceted Roles of TAK1 Signaling in Cancer Mukhopadhyay, Himadri Lee, Nam Y. Oncogene Article Context-specific signaling is a prevalent theme in cancer biology wherein individual molecules and pathways can have multiple or even opposite effects depending on the tumor type. TAK1 represents a particularly notable example of such signaling diversity in cancer progression. Originally discovered as a TGF-β-activated kinase, over the years it has been shown to respond to numerous other stimuli to phosphorylate a wide range of downstream targets and elicit distinct cellular responses across cell and tissue types. Here we present a comprehensive review of TAK1 signaling and provide important therapeutic perspectives related to its function in different cancers. 2019-11-06 2020-02 /pmc/articles/PMC7023988/ /pubmed/31695153 http://dx.doi.org/10.1038/s41388-019-1088-8 Text en Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Mukhopadhyay, Himadri
Lee, Nam Y.
Multifaceted Roles of TAK1 Signaling in Cancer
title Multifaceted Roles of TAK1 Signaling in Cancer
title_full Multifaceted Roles of TAK1 Signaling in Cancer
title_fullStr Multifaceted Roles of TAK1 Signaling in Cancer
title_full_unstemmed Multifaceted Roles of TAK1 Signaling in Cancer
title_short Multifaceted Roles of TAK1 Signaling in Cancer
title_sort multifaceted roles of tak1 signaling in cancer
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7023988/
https://www.ncbi.nlm.nih.gov/pubmed/31695153
http://dx.doi.org/10.1038/s41388-019-1088-8
work_keys_str_mv AT mukhopadhyayhimadri multifacetedrolesoftak1signalingincancer
AT leenamy multifacetedrolesoftak1signalingincancer