The Synthesis and Functional Study of Multicolor Nitrogen-Doped Carbon Dots for Live Cell Nuclear Imaging

The nitrogen-doped carbon dots (N-CQDs) were synthesized by citric acid as a raw material and propylene diamine as a passivation agent. Structure, optical properties and biocompatibility of N-CQDs were analyzed. It was found that the N-CQDs possessed concentration-dependent, multicolor photoluminesc...

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Detalles Bibliográficos
Autores principales: Zhang, Yanan, Zhang, Xingwei, Shi, Yanping, Sun, Chao, Zhou, Nan, Wen, Haixia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7024153/
https://www.ncbi.nlm.nih.gov/pubmed/31940913
http://dx.doi.org/10.3390/molecules25020306
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author Zhang, Yanan
Zhang, Xingwei
Shi, Yanping
Sun, Chao
Zhou, Nan
Wen, Haixia
author_facet Zhang, Yanan
Zhang, Xingwei
Shi, Yanping
Sun, Chao
Zhou, Nan
Wen, Haixia
author_sort Zhang, Yanan
collection PubMed
description The nitrogen-doped carbon dots (N-CQDs) were synthesized by citric acid as a raw material and propylene diamine as a passivation agent. Structure, optical properties and biocompatibility of N-CQDs were analyzed. It was found that the N-CQDs possessed concentration-dependent, multicolor photoluminescence and low toxicity. As demonstrated in the imaging of bioluminescence, by adjusting the concentration of N-CQDs, the cell imaging effect can be adjusted. The internalized N-CQDs were concentrated in the nucleus. A novel tool for studying the nuclear changes during the cell cycle was developed.
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spelling pubmed-70241532020-03-19 The Synthesis and Functional Study of Multicolor Nitrogen-Doped Carbon Dots for Live Cell Nuclear Imaging Zhang, Yanan Zhang, Xingwei Shi, Yanping Sun, Chao Zhou, Nan Wen, Haixia Molecules Article The nitrogen-doped carbon dots (N-CQDs) were synthesized by citric acid as a raw material and propylene diamine as a passivation agent. Structure, optical properties and biocompatibility of N-CQDs were analyzed. It was found that the N-CQDs possessed concentration-dependent, multicolor photoluminescence and low toxicity. As demonstrated in the imaging of bioluminescence, by adjusting the concentration of N-CQDs, the cell imaging effect can be adjusted. The internalized N-CQDs were concentrated in the nucleus. A novel tool for studying the nuclear changes during the cell cycle was developed. MDPI 2020-01-12 /pmc/articles/PMC7024153/ /pubmed/31940913 http://dx.doi.org/10.3390/molecules25020306 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Zhang, Yanan
Zhang, Xingwei
Shi, Yanping
Sun, Chao
Zhou, Nan
Wen, Haixia
The Synthesis and Functional Study of Multicolor Nitrogen-Doped Carbon Dots for Live Cell Nuclear Imaging
title The Synthesis and Functional Study of Multicolor Nitrogen-Doped Carbon Dots for Live Cell Nuclear Imaging
title_full The Synthesis and Functional Study of Multicolor Nitrogen-Doped Carbon Dots for Live Cell Nuclear Imaging
title_fullStr The Synthesis and Functional Study of Multicolor Nitrogen-Doped Carbon Dots for Live Cell Nuclear Imaging
title_full_unstemmed The Synthesis and Functional Study of Multicolor Nitrogen-Doped Carbon Dots for Live Cell Nuclear Imaging
title_short The Synthesis and Functional Study of Multicolor Nitrogen-Doped Carbon Dots for Live Cell Nuclear Imaging
title_sort synthesis and functional study of multicolor nitrogen-doped carbon dots for live cell nuclear imaging
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7024153/
https://www.ncbi.nlm.nih.gov/pubmed/31940913
http://dx.doi.org/10.3390/molecules25020306
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