Solubility and Bioavailability Enhancement of Oridonin: A Review

Oridonin (ORI), an ent-kaurene tetracyclic diterpenoid compound, is isolated from Chinese herb Rabdosia rubescens with various biological and pharmacological activities including anti-tumor, anti-microbial and anti-inflammatory effects. However, the clinical application of ORI is limited due to its...

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Detalles Bibliográficos
Autores principales: Zhang, Yuanyuan, Wang, Shaohua, Dai, Mengmeng, Nai, Jijuan, Zhu, Liqiao, Sheng, Huagang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7024198/
https://www.ncbi.nlm.nih.gov/pubmed/31947574
http://dx.doi.org/10.3390/molecules25020332
Descripción
Sumario:Oridonin (ORI), an ent-kaurene tetracyclic diterpenoid compound, is isolated from Chinese herb Rabdosia rubescens with various biological and pharmacological activities including anti-tumor, anti-microbial and anti-inflammatory effects. However, the clinical application of ORI is limited due to its low solubility and poor bioavailability. In order to overcome these shortcomings, many strategies have been explored such as structural modification, new dosage form, etc. This review provides a detailed discussion on the research progress to increase the solubility and bioavailability of ORI.

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