Solubility and Bioavailability Enhancement of Oridonin: A Review

Oridonin (ORI), an ent-kaurene tetracyclic diterpenoid compound, is isolated from Chinese herb Rabdosia rubescens with various biological and pharmacological activities including anti-tumor, anti-microbial and anti-inflammatory effects. However, the clinical application of ORI is limited due to its...

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Detalles Bibliográficos
Autores principales: Zhang, Yuanyuan, Wang, Shaohua, Dai, Mengmeng, Nai, Jijuan, Zhu, Liqiao, Sheng, Huagang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7024198/
https://www.ncbi.nlm.nih.gov/pubmed/31947574
http://dx.doi.org/10.3390/molecules25020332
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author Zhang, Yuanyuan
Wang, Shaohua
Dai, Mengmeng
Nai, Jijuan
Zhu, Liqiao
Sheng, Huagang
author_facet Zhang, Yuanyuan
Wang, Shaohua
Dai, Mengmeng
Nai, Jijuan
Zhu, Liqiao
Sheng, Huagang
author_sort Zhang, Yuanyuan
collection PubMed
description Oridonin (ORI), an ent-kaurene tetracyclic diterpenoid compound, is isolated from Chinese herb Rabdosia rubescens with various biological and pharmacological activities including anti-tumor, anti-microbial and anti-inflammatory effects. However, the clinical application of ORI is limited due to its low solubility and poor bioavailability. In order to overcome these shortcomings, many strategies have been explored such as structural modification, new dosage form, etc. This review provides a detailed discussion on the research progress to increase the solubility and bioavailability of ORI.
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spelling pubmed-70241982020-03-19 Solubility and Bioavailability Enhancement of Oridonin: A Review Zhang, Yuanyuan Wang, Shaohua Dai, Mengmeng Nai, Jijuan Zhu, Liqiao Sheng, Huagang Molecules Review Oridonin (ORI), an ent-kaurene tetracyclic diterpenoid compound, is isolated from Chinese herb Rabdosia rubescens with various biological and pharmacological activities including anti-tumor, anti-microbial and anti-inflammatory effects. However, the clinical application of ORI is limited due to its low solubility and poor bioavailability. In order to overcome these shortcomings, many strategies have been explored such as structural modification, new dosage form, etc. This review provides a detailed discussion on the research progress to increase the solubility and bioavailability of ORI. MDPI 2020-01-14 /pmc/articles/PMC7024198/ /pubmed/31947574 http://dx.doi.org/10.3390/molecules25020332 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Zhang, Yuanyuan
Wang, Shaohua
Dai, Mengmeng
Nai, Jijuan
Zhu, Liqiao
Sheng, Huagang
Solubility and Bioavailability Enhancement of Oridonin: A Review
title Solubility and Bioavailability Enhancement of Oridonin: A Review
title_full Solubility and Bioavailability Enhancement of Oridonin: A Review
title_fullStr Solubility and Bioavailability Enhancement of Oridonin: A Review
title_full_unstemmed Solubility and Bioavailability Enhancement of Oridonin: A Review
title_short Solubility and Bioavailability Enhancement of Oridonin: A Review
title_sort solubility and bioavailability enhancement of oridonin: a review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7024198/
https://www.ncbi.nlm.nih.gov/pubmed/31947574
http://dx.doi.org/10.3390/molecules25020332
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