Chiral Thioureas—Preparation and Significance in Asymmetric Synthesis and Medicinal Chemistry

For almost 20 years, thioureas have been experiencing a renaissance of interest with the emerged development of asymmetric organocatalysts. Due to their relatively high acidity and strong hydrogen bond donor capability, they differ significantly from ureas and offer, appropriately modified, great po...

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Autores principales: Steppeler, Franz, Iwan, Dominika, Wojaczyńska, Elżbieta, Wojaczyński, Jacek
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7024223/
https://www.ncbi.nlm.nih.gov/pubmed/31963671
http://dx.doi.org/10.3390/molecules25020401
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author Steppeler, Franz
Iwan, Dominika
Wojaczyńska, Elżbieta
Wojaczyński, Jacek
author_facet Steppeler, Franz
Iwan, Dominika
Wojaczyńska, Elżbieta
Wojaczyński, Jacek
author_sort Steppeler, Franz
collection PubMed
description For almost 20 years, thioureas have been experiencing a renaissance of interest with the emerged development of asymmetric organocatalysts. Due to their relatively high acidity and strong hydrogen bond donor capability, they differ significantly from ureas and offer, appropriately modified, great potential as organocatalysts, chelators, drug candidates, etc. The review focuses on the family of chiral thioureas, presenting an overview of the current state of knowledge on their synthesis and selected applications in stereoselective synthesis and drug development.
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spelling pubmed-70242232020-03-19 Chiral Thioureas—Preparation and Significance in Asymmetric Synthesis and Medicinal Chemistry Steppeler, Franz Iwan, Dominika Wojaczyńska, Elżbieta Wojaczyński, Jacek Molecules Review For almost 20 years, thioureas have been experiencing a renaissance of interest with the emerged development of asymmetric organocatalysts. Due to their relatively high acidity and strong hydrogen bond donor capability, they differ significantly from ureas and offer, appropriately modified, great potential as organocatalysts, chelators, drug candidates, etc. The review focuses on the family of chiral thioureas, presenting an overview of the current state of knowledge on their synthesis and selected applications in stereoselective synthesis and drug development. MDPI 2020-01-18 /pmc/articles/PMC7024223/ /pubmed/31963671 http://dx.doi.org/10.3390/molecules25020401 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Steppeler, Franz
Iwan, Dominika
Wojaczyńska, Elżbieta
Wojaczyński, Jacek
Chiral Thioureas—Preparation and Significance in Asymmetric Synthesis and Medicinal Chemistry
title Chiral Thioureas—Preparation and Significance in Asymmetric Synthesis and Medicinal Chemistry
title_full Chiral Thioureas—Preparation and Significance in Asymmetric Synthesis and Medicinal Chemistry
title_fullStr Chiral Thioureas—Preparation and Significance in Asymmetric Synthesis and Medicinal Chemistry
title_full_unstemmed Chiral Thioureas—Preparation and Significance in Asymmetric Synthesis and Medicinal Chemistry
title_short Chiral Thioureas—Preparation and Significance in Asymmetric Synthesis and Medicinal Chemistry
title_sort chiral thioureas—preparation and significance in asymmetric synthesis and medicinal chemistry
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7024223/
https://www.ncbi.nlm.nih.gov/pubmed/31963671
http://dx.doi.org/10.3390/molecules25020401
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