Halogenated Diterpenes with In Vitro Antitumor Activity from the Red Alga Sphaerococcus coronopifolius

Eight new (1–8) structurally diverse diterpenes featuring five different carbocycles were isolated from the organic extracts of the red alga Sphaerococcus coronopifolius collected from the coastline of the Ionian Sea in Greece. The structures of the new natural products, seven of which were halogena...

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Autores principales: Smyrniotopoulos, Vangelis, de Andrade Tomaz, Anna Cláudia, Vanderlei de Souza, Maria de Fátima, Leitão da Cunha, Emídio Vasconcelos, Kiss, Robert, Mathieu, Véronique, Ioannou, Efstathia, Roussis, Vassilios
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7024270/
https://www.ncbi.nlm.nih.gov/pubmed/31905719
http://dx.doi.org/10.3390/md18010029
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author Smyrniotopoulos, Vangelis
de Andrade Tomaz, Anna Cláudia
Vanderlei de Souza, Maria de Fátima
Leitão da Cunha, Emídio Vasconcelos
Kiss, Robert
Mathieu, Véronique
Ioannou, Efstathia
Roussis, Vassilios
author_facet Smyrniotopoulos, Vangelis
de Andrade Tomaz, Anna Cláudia
Vanderlei de Souza, Maria de Fátima
Leitão da Cunha, Emídio Vasconcelos
Kiss, Robert
Mathieu, Véronique
Ioannou, Efstathia
Roussis, Vassilios
author_sort Smyrniotopoulos, Vangelis
collection PubMed
description Eight new (1–8) structurally diverse diterpenes featuring five different carbocycles were isolated from the organic extracts of the red alga Sphaerococcus coronopifolius collected from the coastline of the Ionian Sea in Greece. The structures of the new natural products, seven of which were halogenated, and the relative configuration of their stereocenters were determined on the basis of comprehensive spectroscopic analyses, including NMR and HRMS data. Compounds 5 and 8 were found to possess in vitro antitumor activity against one murine and five human cancer cell lines with mean IC(50) values 15 and 16 μM, respectively.
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spelling pubmed-70242702020-03-11 Halogenated Diterpenes with In Vitro Antitumor Activity from the Red Alga Sphaerococcus coronopifolius Smyrniotopoulos, Vangelis de Andrade Tomaz, Anna Cláudia Vanderlei de Souza, Maria de Fátima Leitão da Cunha, Emídio Vasconcelos Kiss, Robert Mathieu, Véronique Ioannou, Efstathia Roussis, Vassilios Mar Drugs Article Eight new (1–8) structurally diverse diterpenes featuring five different carbocycles were isolated from the organic extracts of the red alga Sphaerococcus coronopifolius collected from the coastline of the Ionian Sea in Greece. The structures of the new natural products, seven of which were halogenated, and the relative configuration of their stereocenters were determined on the basis of comprehensive spectroscopic analyses, including NMR and HRMS data. Compounds 5 and 8 were found to possess in vitro antitumor activity against one murine and five human cancer cell lines with mean IC(50) values 15 and 16 μM, respectively. MDPI 2019-12-29 /pmc/articles/PMC7024270/ /pubmed/31905719 http://dx.doi.org/10.3390/md18010029 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Smyrniotopoulos, Vangelis
de Andrade Tomaz, Anna Cláudia
Vanderlei de Souza, Maria de Fátima
Leitão da Cunha, Emídio Vasconcelos
Kiss, Robert
Mathieu, Véronique
Ioannou, Efstathia
Roussis, Vassilios
Halogenated Diterpenes with In Vitro Antitumor Activity from the Red Alga Sphaerococcus coronopifolius
title Halogenated Diterpenes with In Vitro Antitumor Activity from the Red Alga Sphaerococcus coronopifolius
title_full Halogenated Diterpenes with In Vitro Antitumor Activity from the Red Alga Sphaerococcus coronopifolius
title_fullStr Halogenated Diterpenes with In Vitro Antitumor Activity from the Red Alga Sphaerococcus coronopifolius
title_full_unstemmed Halogenated Diterpenes with In Vitro Antitumor Activity from the Red Alga Sphaerococcus coronopifolius
title_short Halogenated Diterpenes with In Vitro Antitumor Activity from the Red Alga Sphaerococcus coronopifolius
title_sort halogenated diterpenes with in vitro antitumor activity from the red alga sphaerococcus coronopifolius
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7024270/
https://www.ncbi.nlm.nih.gov/pubmed/31905719
http://dx.doi.org/10.3390/md18010029
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