The Role of Macrophage Migration Inhibitory Factor in Alzheimer′s Disease: Conventionally Pathogenetic or Unconventionally Protective?

Recent preclinical and clinical observations have offered relevant insights on the etiopathogenesis of late onset Alzheimer′s disease (AD) and upregulated immunoinflammatory events have been described as underlying mechanisms involved in the development of AD. Macrophage migration inhibitory factor...

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Autores principales: Petralia, Maria Cristina, Battaglia, Giuseppe, Bruno, Valeria, Pennisi, Manuela, Mangano, Katia, Lombardo, Salvo Danilo, Fagone, Paolo, Cavalli, Eugenio, Saraceno, Andrea, Nicoletti, Ferdinando, Basile, Maria Sofia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7024279/
https://www.ncbi.nlm.nih.gov/pubmed/31936865
http://dx.doi.org/10.3390/molecules25020291
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author Petralia, Maria Cristina
Battaglia, Giuseppe
Bruno, Valeria
Pennisi, Manuela
Mangano, Katia
Lombardo, Salvo Danilo
Fagone, Paolo
Cavalli, Eugenio
Saraceno, Andrea
Nicoletti, Ferdinando
Basile, Maria Sofia
author_facet Petralia, Maria Cristina
Battaglia, Giuseppe
Bruno, Valeria
Pennisi, Manuela
Mangano, Katia
Lombardo, Salvo Danilo
Fagone, Paolo
Cavalli, Eugenio
Saraceno, Andrea
Nicoletti, Ferdinando
Basile, Maria Sofia
author_sort Petralia, Maria Cristina
collection PubMed
description Recent preclinical and clinical observations have offered relevant insights on the etiopathogenesis of late onset Alzheimer′s disease (AD) and upregulated immunoinflammatory events have been described as underlying mechanisms involved in the development of AD. Macrophage migration inhibitory factor (MIF) is a pleiotropic cytokine produced by several cells of the innate and adaptive immune system, as well as non-immune cells. In the present review, we highlight experimental, genetic, and clinical studies on MIF in rodent models of AD and AD patients, and we discuss emerging therapeutic opportunities for tailored modulation of the activity of MIF, that may potentially be applied to AD patients. Dismantling the exact role of MIF and its receptors in AD may offer novel diagnostic and therapeutic opportunities in AD.
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spelling pubmed-70242792020-03-11 The Role of Macrophage Migration Inhibitory Factor in Alzheimer′s Disease: Conventionally Pathogenetic or Unconventionally Protective? Petralia, Maria Cristina Battaglia, Giuseppe Bruno, Valeria Pennisi, Manuela Mangano, Katia Lombardo, Salvo Danilo Fagone, Paolo Cavalli, Eugenio Saraceno, Andrea Nicoletti, Ferdinando Basile, Maria Sofia Molecules Review Recent preclinical and clinical observations have offered relevant insights on the etiopathogenesis of late onset Alzheimer′s disease (AD) and upregulated immunoinflammatory events have been described as underlying mechanisms involved in the development of AD. Macrophage migration inhibitory factor (MIF) is a pleiotropic cytokine produced by several cells of the innate and adaptive immune system, as well as non-immune cells. In the present review, we highlight experimental, genetic, and clinical studies on MIF in rodent models of AD and AD patients, and we discuss emerging therapeutic opportunities for tailored modulation of the activity of MIF, that may potentially be applied to AD patients. Dismantling the exact role of MIF and its receptors in AD may offer novel diagnostic and therapeutic opportunities in AD. MDPI 2020-01-10 /pmc/articles/PMC7024279/ /pubmed/31936865 http://dx.doi.org/10.3390/molecules25020291 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Petralia, Maria Cristina
Battaglia, Giuseppe
Bruno, Valeria
Pennisi, Manuela
Mangano, Katia
Lombardo, Salvo Danilo
Fagone, Paolo
Cavalli, Eugenio
Saraceno, Andrea
Nicoletti, Ferdinando
Basile, Maria Sofia
The Role of Macrophage Migration Inhibitory Factor in Alzheimer′s Disease: Conventionally Pathogenetic or Unconventionally Protective?
title The Role of Macrophage Migration Inhibitory Factor in Alzheimer′s Disease: Conventionally Pathogenetic or Unconventionally Protective?
title_full The Role of Macrophage Migration Inhibitory Factor in Alzheimer′s Disease: Conventionally Pathogenetic or Unconventionally Protective?
title_fullStr The Role of Macrophage Migration Inhibitory Factor in Alzheimer′s Disease: Conventionally Pathogenetic or Unconventionally Protective?
title_full_unstemmed The Role of Macrophage Migration Inhibitory Factor in Alzheimer′s Disease: Conventionally Pathogenetic or Unconventionally Protective?
title_short The Role of Macrophage Migration Inhibitory Factor in Alzheimer′s Disease: Conventionally Pathogenetic or Unconventionally Protective?
title_sort role of macrophage migration inhibitory factor in alzheimer′s disease: conventionally pathogenetic or unconventionally protective?
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7024279/
https://www.ncbi.nlm.nih.gov/pubmed/31936865
http://dx.doi.org/10.3390/molecules25020291
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