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Divergent Asymmetric Total Synthesis of All Four Pestalotin Diastereomers from (R)-Glycidol

All four chiral pestalotin diastereomers were synthesized in a straightforward and divergent manner from common (R)-glycidol. Catalytic asymmetric Mukaiyama aldol reactions of readily-available bis(TMSO)diene (Chan’s diene) with (S)-2-benzyloxyhexanal derived from (R)-glycidol produced a syn-aldol a...

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Detalles Bibliográficos
Autores principales:	Moriyama, Mizuki, Nakata, Kohei, Fujiwara, Tetsuya, Tanabe, Yoo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7024299/ https://www.ncbi.nlm.nih.gov/pubmed/31963564 http://dx.doi.org/10.3390/molecules25020394

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