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Constituents from the Seeds of Sophora Alopecuroides L.
Three new isoflavone glucosides, kudonol A−C (1–3), two new ester derivatives of phenylpropanoid, kudolignan A and B (4–5) and five known compounds, (−)-maackiain (6), neoliquiritin (7), methyl 4-coumarate (8), methyl ferulate (9) and (+)-wikstromol (10), were isolated from an extract of dried seeds...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7024312/ https://www.ncbi.nlm.nih.gov/pubmed/31963799 http://dx.doi.org/10.3390/molecules25020411 |
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author | Rong, Zi-Jian Hu, Gao-Sheng Lin, Shi-Yi Yan, Ting Li, Na Zhao, Yue Jia, Jing-Ming Wang, An-Hua |
author_facet | Rong, Zi-Jian Hu, Gao-Sheng Lin, Shi-Yi Yan, Ting Li, Na Zhao, Yue Jia, Jing-Ming Wang, An-Hua |
author_sort | Rong, Zi-Jian |
collection | PubMed |
description | Three new isoflavone glucosides, kudonol A−C (1–3), two new ester derivatives of phenylpropanoid, kudolignan A and B (4–5) and five known compounds, (−)-maackiain (6), neoliquiritin (7), methyl 4-coumarate (8), methyl ferulate (9) and (+)-wikstromol (10), were isolated from an extract of dried seeds of the traditional Chinese medicinal plant Sophora alopecuroides L. Their structures were established by NMR and HRESIMS data analyses. The monosaccharide part’s configuration of isoflavone glucosides was confirmed by acid hydrolysis and analyzed by a JAsco OR-4090 chiral detector, comparing it to standard substance D-glucose. The cytotoxicity effects against HeLa, Hep3B, MCF-7 and H1299 cells were tested by CCK-8 assay. |
format | Online Article Text |
id | pubmed-7024312 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-70243122020-03-11 Constituents from the Seeds of Sophora Alopecuroides L. Rong, Zi-Jian Hu, Gao-Sheng Lin, Shi-Yi Yan, Ting Li, Na Zhao, Yue Jia, Jing-Ming Wang, An-Hua Molecules Article Three new isoflavone glucosides, kudonol A−C (1–3), two new ester derivatives of phenylpropanoid, kudolignan A and B (4–5) and five known compounds, (−)-maackiain (6), neoliquiritin (7), methyl 4-coumarate (8), methyl ferulate (9) and (+)-wikstromol (10), were isolated from an extract of dried seeds of the traditional Chinese medicinal plant Sophora alopecuroides L. Their structures were established by NMR and HRESIMS data analyses. The monosaccharide part’s configuration of isoflavone glucosides was confirmed by acid hydrolysis and analyzed by a JAsco OR-4090 chiral detector, comparing it to standard substance D-glucose. The cytotoxicity effects against HeLa, Hep3B, MCF-7 and H1299 cells were tested by CCK-8 assay. MDPI 2020-01-19 /pmc/articles/PMC7024312/ /pubmed/31963799 http://dx.doi.org/10.3390/molecules25020411 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Rong, Zi-Jian Hu, Gao-Sheng Lin, Shi-Yi Yan, Ting Li, Na Zhao, Yue Jia, Jing-Ming Wang, An-Hua Constituents from the Seeds of Sophora Alopecuroides L. |
title | Constituents from the Seeds of Sophora Alopecuroides L. |
title_full | Constituents from the Seeds of Sophora Alopecuroides L. |
title_fullStr | Constituents from the Seeds of Sophora Alopecuroides L. |
title_full_unstemmed | Constituents from the Seeds of Sophora Alopecuroides L. |
title_short | Constituents from the Seeds of Sophora Alopecuroides L. |
title_sort | constituents from the seeds of sophora alopecuroides l. |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7024312/ https://www.ncbi.nlm.nih.gov/pubmed/31963799 http://dx.doi.org/10.3390/molecules25020411 |
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