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Structure-Based Virtual Screening, Molecular Dynamics and Binding Free Energy Calculations of Hit Candidates as ALK-5 Inhibitors

Activin-like kinase 5 (ALK-5) is involved in the physiopathology of several conditions, such as pancreatic carcinoma, cervical cancer and liver hepatoma. Cellular events that are landmarks of tumorigenesis, such as loss of cell polarity and acquisition of motile properties and mesenchymal phenotype,...

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Detalles Bibliográficos
Autores principales:	Araujo, Sheila C., Maltarollo, Vinicius G., Almeida, Michell O., Ferreira, Leonardo L. G., Andricopulo, Adriano D., Honorio, Kathia M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7024315/ https://www.ncbi.nlm.nih.gov/pubmed/31936488 http://dx.doi.org/10.3390/molecules25020264

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