Altertoxins with Quorum Sensing Inhibitory Activities from The Marine-Derived Fungus Cladosporium sp. KFD33

Five new perylenequinone derivatives, altertoxins VIII–XII (1–5), as well as one known compound cladosporol I (6), were isolated from the fermentation broth of the marine-derived fungus Cladosporium sp. KFD33 from a blood cockle from Haikou Bay, China. Their structures were determined based on spect...

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Autores principales: Zhang, Fei, Zhou, Liman, Kong, Fandong, Ma, Qingyun, Xie, Qingyi, Li, Jiuhui, Dai, Haofu, Guo, Lei, Zhao, Youxing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7024320/
https://www.ncbi.nlm.nih.gov/pubmed/31963874
http://dx.doi.org/10.3390/md18010067
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author Zhang, Fei
Zhou, Liman
Kong, Fandong
Ma, Qingyun
Xie, Qingyi
Li, Jiuhui
Dai, Haofu
Guo, Lei
Zhao, Youxing
author_facet Zhang, Fei
Zhou, Liman
Kong, Fandong
Ma, Qingyun
Xie, Qingyi
Li, Jiuhui
Dai, Haofu
Guo, Lei
Zhao, Youxing
author_sort Zhang, Fei
collection PubMed
description Five new perylenequinone derivatives, altertoxins VIII–XII (1–5), as well as one known compound cladosporol I (6), were isolated from the fermentation broth of the marine-derived fungus Cladosporium sp. KFD33 from a blood cockle from Haikou Bay, China. Their structures were determined based on spectroscopic methods and ECD spectra analysis along with quantum ECD calculations. Compounds 1–6 exhibited quorum sensing inhibitory activities against Chromobacterium violaceum CV026 with MIC values of 30, 30, 20, 30, 20 and 30 μg/well, respectively.
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spelling pubmed-70243202020-03-11 Altertoxins with Quorum Sensing Inhibitory Activities from The Marine-Derived Fungus Cladosporium sp. KFD33 Zhang, Fei Zhou, Liman Kong, Fandong Ma, Qingyun Xie, Qingyi Li, Jiuhui Dai, Haofu Guo, Lei Zhao, Youxing Mar Drugs Article Five new perylenequinone derivatives, altertoxins VIII–XII (1–5), as well as one known compound cladosporol I (6), were isolated from the fermentation broth of the marine-derived fungus Cladosporium sp. KFD33 from a blood cockle from Haikou Bay, China. Their structures were determined based on spectroscopic methods and ECD spectra analysis along with quantum ECD calculations. Compounds 1–6 exhibited quorum sensing inhibitory activities against Chromobacterium violaceum CV026 with MIC values of 30, 30, 20, 30, 20 and 30 μg/well, respectively. MDPI 2020-01-19 /pmc/articles/PMC7024320/ /pubmed/31963874 http://dx.doi.org/10.3390/md18010067 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Zhang, Fei
Zhou, Liman
Kong, Fandong
Ma, Qingyun
Xie, Qingyi
Li, Jiuhui
Dai, Haofu
Guo, Lei
Zhao, Youxing
Altertoxins with Quorum Sensing Inhibitory Activities from The Marine-Derived Fungus Cladosporium sp. KFD33
title Altertoxins with Quorum Sensing Inhibitory Activities from The Marine-Derived Fungus Cladosporium sp. KFD33
title_full Altertoxins with Quorum Sensing Inhibitory Activities from The Marine-Derived Fungus Cladosporium sp. KFD33
title_fullStr Altertoxins with Quorum Sensing Inhibitory Activities from The Marine-Derived Fungus Cladosporium sp. KFD33
title_full_unstemmed Altertoxins with Quorum Sensing Inhibitory Activities from The Marine-Derived Fungus Cladosporium sp. KFD33
title_short Altertoxins with Quorum Sensing Inhibitory Activities from The Marine-Derived Fungus Cladosporium sp. KFD33
title_sort altertoxins with quorum sensing inhibitory activities from the marine-derived fungus cladosporium sp. kfd33
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7024320/
https://www.ncbi.nlm.nih.gov/pubmed/31963874
http://dx.doi.org/10.3390/md18010067
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