Rhodium(III)-Catalyzed Redox-Neutral [3+3] Annulation of N-nitrosoanilines with Cyclopropenones: A Traceless Approach to Quinolin-4(1H)-One Scaffolds

A traceless approach to quinolin-4(1H)-one scaffolds through Rh(III)-catalyzed redox-neutral [3+3] cyclization of N-nitrosoanilines with cyclopropenones has been achieved. This protocol features short reaction time and atom-economical combination without extra additives, which can be further applied...

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Detalles Bibliográficos
Autores principales: Liu, Lingjun, Li, Jiyuan, Dai, Wenhao, Gao, Feng, Chen, Kaixian, Zhou, Yu, Liu, Hong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7024356/
https://www.ncbi.nlm.nih.gov/pubmed/31936532
http://dx.doi.org/10.3390/molecules25020268
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author Liu, Lingjun
Li, Jiyuan
Dai, Wenhao
Gao, Feng
Chen, Kaixian
Zhou, Yu
Liu, Hong
author_facet Liu, Lingjun
Li, Jiyuan
Dai, Wenhao
Gao, Feng
Chen, Kaixian
Zhou, Yu
Liu, Hong
author_sort Liu, Lingjun
collection PubMed
description A traceless approach to quinolin-4(1H)-one scaffolds through Rh(III)-catalyzed redox-neutral [3+3] cyclization of N-nitrosoanilines with cyclopropenones has been achieved. This protocol features short reaction time and atom-economical combination without extra additives, which can be further applied in the construction of privileged heterocyclic compounds in pharmaceutical chemistry.
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spelling pubmed-70243562020-03-11 Rhodium(III)-Catalyzed Redox-Neutral [3+3] Annulation of N-nitrosoanilines with Cyclopropenones: A Traceless Approach to Quinolin-4(1H)-One Scaffolds Liu, Lingjun Li, Jiyuan Dai, Wenhao Gao, Feng Chen, Kaixian Zhou, Yu Liu, Hong Molecules Article A traceless approach to quinolin-4(1H)-one scaffolds through Rh(III)-catalyzed redox-neutral [3+3] cyclization of N-nitrosoanilines with cyclopropenones has been achieved. This protocol features short reaction time and atom-economical combination without extra additives, which can be further applied in the construction of privileged heterocyclic compounds in pharmaceutical chemistry. MDPI 2020-01-09 /pmc/articles/PMC7024356/ /pubmed/31936532 http://dx.doi.org/10.3390/molecules25020268 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Liu, Lingjun
Li, Jiyuan
Dai, Wenhao
Gao, Feng
Chen, Kaixian
Zhou, Yu
Liu, Hong
Rhodium(III)-Catalyzed Redox-Neutral [3+3] Annulation of N-nitrosoanilines with Cyclopropenones: A Traceless Approach to Quinolin-4(1H)-One Scaffolds
title Rhodium(III)-Catalyzed Redox-Neutral [3+3] Annulation of N-nitrosoanilines with Cyclopropenones: A Traceless Approach to Quinolin-4(1H)-One Scaffolds
title_full Rhodium(III)-Catalyzed Redox-Neutral [3+3] Annulation of N-nitrosoanilines with Cyclopropenones: A Traceless Approach to Quinolin-4(1H)-One Scaffolds
title_fullStr Rhodium(III)-Catalyzed Redox-Neutral [3+3] Annulation of N-nitrosoanilines with Cyclopropenones: A Traceless Approach to Quinolin-4(1H)-One Scaffolds
title_full_unstemmed Rhodium(III)-Catalyzed Redox-Neutral [3+3] Annulation of N-nitrosoanilines with Cyclopropenones: A Traceless Approach to Quinolin-4(1H)-One Scaffolds
title_short Rhodium(III)-Catalyzed Redox-Neutral [3+3] Annulation of N-nitrosoanilines with Cyclopropenones: A Traceless Approach to Quinolin-4(1H)-One Scaffolds
title_sort rhodium(iii)-catalyzed redox-neutral [3+3] annulation of n-nitrosoanilines with cyclopropenones: a traceless approach to quinolin-4(1h)-one scaffolds
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7024356/
https://www.ncbi.nlm.nih.gov/pubmed/31936532
http://dx.doi.org/10.3390/molecules25020268
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