Oxidative Dearomative Cross-Dehydrogenative Coupling of Indoles with Diverse C-H Nucleophiles: Efficient Approach to 2,2-Disubstituted Indolin-3-ones

The oxidative, dearomative cross-dehydrogenative coupling of indoles with various C-H nucleophiles is developed. This process features a broad substrate scope with respect to both indoles and nucleophiles, affording structurally diverse 2,2-disubstituted indolin-3-ones in high yields (up to 99%). Th...

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Detalles Bibliográficos
Autores principales: Yan, Xue, Tang, Ying-De, Jiang, Cheng-Shi, Liu, Xigong, Zhang, Hua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7024378/
https://www.ncbi.nlm.nih.gov/pubmed/31968572
http://dx.doi.org/10.3390/molecules25020419
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author Yan, Xue
Tang, Ying-De
Jiang, Cheng-Shi
Liu, Xigong
Zhang, Hua
author_facet Yan, Xue
Tang, Ying-De
Jiang, Cheng-Shi
Liu, Xigong
Zhang, Hua
author_sort Yan, Xue
collection PubMed
description The oxidative, dearomative cross-dehydrogenative coupling of indoles with various C-H nucleophiles is developed. This process features a broad substrate scope with respect to both indoles and nucleophiles, affording structurally diverse 2,2-disubstituted indolin-3-ones in high yields (up to 99%). The oxidative dimerization and trimerization of indoles has also been demonstrated under the same conditions.
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spelling pubmed-70243782020-03-11 Oxidative Dearomative Cross-Dehydrogenative Coupling of Indoles with Diverse C-H Nucleophiles: Efficient Approach to 2,2-Disubstituted Indolin-3-ones Yan, Xue Tang, Ying-De Jiang, Cheng-Shi Liu, Xigong Zhang, Hua Molecules Article The oxidative, dearomative cross-dehydrogenative coupling of indoles with various C-H nucleophiles is developed. This process features a broad substrate scope with respect to both indoles and nucleophiles, affording structurally diverse 2,2-disubstituted indolin-3-ones in high yields (up to 99%). The oxidative dimerization and trimerization of indoles has also been demonstrated under the same conditions. MDPI 2020-01-20 /pmc/articles/PMC7024378/ /pubmed/31968572 http://dx.doi.org/10.3390/molecules25020419 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Yan, Xue
Tang, Ying-De
Jiang, Cheng-Shi
Liu, Xigong
Zhang, Hua
Oxidative Dearomative Cross-Dehydrogenative Coupling of Indoles with Diverse C-H Nucleophiles: Efficient Approach to 2,2-Disubstituted Indolin-3-ones
title Oxidative Dearomative Cross-Dehydrogenative Coupling of Indoles with Diverse C-H Nucleophiles: Efficient Approach to 2,2-Disubstituted Indolin-3-ones
title_full Oxidative Dearomative Cross-Dehydrogenative Coupling of Indoles with Diverse C-H Nucleophiles: Efficient Approach to 2,2-Disubstituted Indolin-3-ones
title_fullStr Oxidative Dearomative Cross-Dehydrogenative Coupling of Indoles with Diverse C-H Nucleophiles: Efficient Approach to 2,2-Disubstituted Indolin-3-ones
title_full_unstemmed Oxidative Dearomative Cross-Dehydrogenative Coupling of Indoles with Diverse C-H Nucleophiles: Efficient Approach to 2,2-Disubstituted Indolin-3-ones
title_short Oxidative Dearomative Cross-Dehydrogenative Coupling of Indoles with Diverse C-H Nucleophiles: Efficient Approach to 2,2-Disubstituted Indolin-3-ones
title_sort oxidative dearomative cross-dehydrogenative coupling of indoles with diverse c-h nucleophiles: efficient approach to 2,2-disubstituted indolin-3-ones
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7024378/
https://www.ncbi.nlm.nih.gov/pubmed/31968572
http://dx.doi.org/10.3390/molecules25020419
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