Cargando…
Anthocyanin Metabolites in Human Urine after the Intake of New Functional Beverages
Sugar intake abuse is directly related with the increase of metabolic diseases such as type 2 diabetes, obesity, and insulin resistance. Along this line, the development of new beverages using alternative sweeteners could help with combatting the pathophysiological disorders associated to the consum...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7024541/ https://www.ncbi.nlm.nih.gov/pubmed/31963236 http://dx.doi.org/10.3390/molecules25020371 |
_version_ | 1783498426970800128 |
---|---|
author | Agulló, Vicente Villaño, Débora García-Viguera, Cristina Domínguez-Perles, Raúl |
author_facet | Agulló, Vicente Villaño, Débora García-Viguera, Cristina Domínguez-Perles, Raúl |
author_sort | Agulló, Vicente |
collection | PubMed |
description | Sugar intake abuse is directly related with the increase of metabolic diseases such as type 2 diabetes, obesity, and insulin resistance. Along this line, the development of new beverages using alternative sweeteners could help with combatting the pathophysiological disorders associated to the consumption of sugar. To provide evidence on this issue, in the present work, the bioavailability of anthocyanins was evaluated after the acute ingestion of a new maqui-citrus-based functional beverage rich in polyphenols, and supplemented with a range of sweeteners including sucrose (natural high caloric), stevia (natural non-caloric), and sucralose (artificial non-caloric), as an approach that would allow reducing the intake of sugars while providing bioactive phenolic compounds (anthocyanins). This approach allowed the evaluation of the maximum absorption and the diversity of metabolites excreted through urine. The beverages created were ingested by volunteers (n = 20) and the resulting anthocyanin metabolites in their urine were analyzed by UHPLC-ESI-MS/MS. A total of 29 degradation metabolites were detected: Caffeic acid, catechol, 3,4-dihidroxifenilacetic acid, hippuric acid, trans-ferulic acid, 2,4,6-trihydroxybenzaldehyde, trans-isoferulic acid, and vanillic acid derivatives, where peak concentrations were attained at 3.5 h after beverage intake. Sucralose was the sweetener that provided a higher bioavailability for most compounds, followed by stevia. Sucrose did not provide a remarkably higher bioavailability of any compounds in comparison with sucralose or stevia. The results propose two sweetener alternatives (sucralose and stevia) to sucrose, an overused high calorie sweetener that promotes some metabolic diseases. |
format | Online Article Text |
id | pubmed-7024541 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-70245412020-03-11 Anthocyanin Metabolites in Human Urine after the Intake of New Functional Beverages Agulló, Vicente Villaño, Débora García-Viguera, Cristina Domínguez-Perles, Raúl Molecules Article Sugar intake abuse is directly related with the increase of metabolic diseases such as type 2 diabetes, obesity, and insulin resistance. Along this line, the development of new beverages using alternative sweeteners could help with combatting the pathophysiological disorders associated to the consumption of sugar. To provide evidence on this issue, in the present work, the bioavailability of anthocyanins was evaluated after the acute ingestion of a new maqui-citrus-based functional beverage rich in polyphenols, and supplemented with a range of sweeteners including sucrose (natural high caloric), stevia (natural non-caloric), and sucralose (artificial non-caloric), as an approach that would allow reducing the intake of sugars while providing bioactive phenolic compounds (anthocyanins). This approach allowed the evaluation of the maximum absorption and the diversity of metabolites excreted through urine. The beverages created were ingested by volunteers (n = 20) and the resulting anthocyanin metabolites in their urine were analyzed by UHPLC-ESI-MS/MS. A total of 29 degradation metabolites were detected: Caffeic acid, catechol, 3,4-dihidroxifenilacetic acid, hippuric acid, trans-ferulic acid, 2,4,6-trihydroxybenzaldehyde, trans-isoferulic acid, and vanillic acid derivatives, where peak concentrations were attained at 3.5 h after beverage intake. Sucralose was the sweetener that provided a higher bioavailability for most compounds, followed by stevia. Sucrose did not provide a remarkably higher bioavailability of any compounds in comparison with sucralose or stevia. The results propose two sweetener alternatives (sucralose and stevia) to sucrose, an overused high calorie sweetener that promotes some metabolic diseases. MDPI 2020-01-16 /pmc/articles/PMC7024541/ /pubmed/31963236 http://dx.doi.org/10.3390/molecules25020371 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Agulló, Vicente Villaño, Débora García-Viguera, Cristina Domínguez-Perles, Raúl Anthocyanin Metabolites in Human Urine after the Intake of New Functional Beverages |
title | Anthocyanin Metabolites in Human Urine after the Intake of New Functional Beverages |
title_full | Anthocyanin Metabolites in Human Urine after the Intake of New Functional Beverages |
title_fullStr | Anthocyanin Metabolites in Human Urine after the Intake of New Functional Beverages |
title_full_unstemmed | Anthocyanin Metabolites in Human Urine after the Intake of New Functional Beverages |
title_short | Anthocyanin Metabolites in Human Urine after the Intake of New Functional Beverages |
title_sort | anthocyanin metabolites in human urine after the intake of new functional beverages |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7024541/ https://www.ncbi.nlm.nih.gov/pubmed/31963236 http://dx.doi.org/10.3390/molecules25020371 |
work_keys_str_mv | AT agullovicente anthocyaninmetabolitesinhumanurineaftertheintakeofnewfunctionalbeverages AT villanodebora anthocyaninmetabolitesinhumanurineaftertheintakeofnewfunctionalbeverages AT garciavigueracristina anthocyaninmetabolitesinhumanurineaftertheintakeofnewfunctionalbeverages AT dominguezperlesraul anthocyaninmetabolitesinhumanurineaftertheintakeofnewfunctionalbeverages |