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Anthocyanin Metabolites in Human Urine after the Intake of New Functional Beverages

Sugar intake abuse is directly related with the increase of metabolic diseases such as type 2 diabetes, obesity, and insulin resistance. Along this line, the development of new beverages using alternative sweeteners could help with combatting the pathophysiological disorders associated to the consum...

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Autores principales: Agulló, Vicente, Villaño, Débora, García-Viguera, Cristina, Domínguez-Perles, Raúl
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7024541/
https://www.ncbi.nlm.nih.gov/pubmed/31963236
http://dx.doi.org/10.3390/molecules25020371
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author Agulló, Vicente
Villaño, Débora
García-Viguera, Cristina
Domínguez-Perles, Raúl
author_facet Agulló, Vicente
Villaño, Débora
García-Viguera, Cristina
Domínguez-Perles, Raúl
author_sort Agulló, Vicente
collection PubMed
description Sugar intake abuse is directly related with the increase of metabolic diseases such as type 2 diabetes, obesity, and insulin resistance. Along this line, the development of new beverages using alternative sweeteners could help with combatting the pathophysiological disorders associated to the consumption of sugar. To provide evidence on this issue, in the present work, the bioavailability of anthocyanins was evaluated after the acute ingestion of a new maqui-citrus-based functional beverage rich in polyphenols, and supplemented with a range of sweeteners including sucrose (natural high caloric), stevia (natural non-caloric), and sucralose (artificial non-caloric), as an approach that would allow reducing the intake of sugars while providing bioactive phenolic compounds (anthocyanins). This approach allowed the evaluation of the maximum absorption and the diversity of metabolites excreted through urine. The beverages created were ingested by volunteers (n = 20) and the resulting anthocyanin metabolites in their urine were analyzed by UHPLC-ESI-MS/MS. A total of 29 degradation metabolites were detected: Caffeic acid, catechol, 3,4-dihidroxifenilacetic acid, hippuric acid, trans-ferulic acid, 2,4,6-trihydroxybenzaldehyde, trans-isoferulic acid, and vanillic acid derivatives, where peak concentrations were attained at 3.5 h after beverage intake. Sucralose was the sweetener that provided a higher bioavailability for most compounds, followed by stevia. Sucrose did not provide a remarkably higher bioavailability of any compounds in comparison with sucralose or stevia. The results propose two sweetener alternatives (sucralose and stevia) to sucrose, an overused high calorie sweetener that promotes some metabolic diseases.
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spelling pubmed-70245412020-03-11 Anthocyanin Metabolites in Human Urine after the Intake of New Functional Beverages Agulló, Vicente Villaño, Débora García-Viguera, Cristina Domínguez-Perles, Raúl Molecules Article Sugar intake abuse is directly related with the increase of metabolic diseases such as type 2 diabetes, obesity, and insulin resistance. Along this line, the development of new beverages using alternative sweeteners could help with combatting the pathophysiological disorders associated to the consumption of sugar. To provide evidence on this issue, in the present work, the bioavailability of anthocyanins was evaluated after the acute ingestion of a new maqui-citrus-based functional beverage rich in polyphenols, and supplemented with a range of sweeteners including sucrose (natural high caloric), stevia (natural non-caloric), and sucralose (artificial non-caloric), as an approach that would allow reducing the intake of sugars while providing bioactive phenolic compounds (anthocyanins). This approach allowed the evaluation of the maximum absorption and the diversity of metabolites excreted through urine. The beverages created were ingested by volunteers (n = 20) and the resulting anthocyanin metabolites in their urine were analyzed by UHPLC-ESI-MS/MS. A total of 29 degradation metabolites were detected: Caffeic acid, catechol, 3,4-dihidroxifenilacetic acid, hippuric acid, trans-ferulic acid, 2,4,6-trihydroxybenzaldehyde, trans-isoferulic acid, and vanillic acid derivatives, where peak concentrations were attained at 3.5 h after beverage intake. Sucralose was the sweetener that provided a higher bioavailability for most compounds, followed by stevia. Sucrose did not provide a remarkably higher bioavailability of any compounds in comparison with sucralose or stevia. The results propose two sweetener alternatives (sucralose and stevia) to sucrose, an overused high calorie sweetener that promotes some metabolic diseases. MDPI 2020-01-16 /pmc/articles/PMC7024541/ /pubmed/31963236 http://dx.doi.org/10.3390/molecules25020371 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Agulló, Vicente
Villaño, Débora
García-Viguera, Cristina
Domínguez-Perles, Raúl
Anthocyanin Metabolites in Human Urine after the Intake of New Functional Beverages
title Anthocyanin Metabolites in Human Urine after the Intake of New Functional Beverages
title_full Anthocyanin Metabolites in Human Urine after the Intake of New Functional Beverages
title_fullStr Anthocyanin Metabolites in Human Urine after the Intake of New Functional Beverages
title_full_unstemmed Anthocyanin Metabolites in Human Urine after the Intake of New Functional Beverages
title_short Anthocyanin Metabolites in Human Urine after the Intake of New Functional Beverages
title_sort anthocyanin metabolites in human urine after the intake of new functional beverages
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7024541/
https://www.ncbi.nlm.nih.gov/pubmed/31963236
http://dx.doi.org/10.3390/molecules25020371
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