Synthesis, Characterization and DNA Binding Investigations of a New Binuclear Ag(I) Complex and Evaluation of Its Anticancer Property

AIM: A new Ag(I) complex (A(3)) was synthesized and evaluated for its anticancer activity against human cancer cell lines. MATERIALS AND METHODS: The complex A(3) was characterized by (1)H, (13)C, and (31)P nuclear magnetic resonance (NMR), infrared (IR) spectra, elemental analysis, and X-ray crysta...

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Detalles Bibliográficos
Autores principales: Zheng, Mian-Hong, Bigdeli, Fahime, Gao, Lan-Xing, Wu, Deng-Ze, Yan, Xiao-Wei, Hu, Mao-Lin, Morsali, Ali
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2020
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7024786/
https://www.ncbi.nlm.nih.gov/pubmed/32103949
http://dx.doi.org/10.2147/IJN.S225038
Descripción
Sumario:AIM: A new Ag(I) complex (A(3)) was synthesized and evaluated for its anticancer activity against human cancer cell lines. MATERIALS AND METHODS: The complex A(3) was characterized by (1)H, (13)C, and (31)P nuclear magnetic resonance (NMR), infrared (IR) spectra, elemental analysis, and X-ray crystallography. The interaction of the complex with CT-DNA was studied by electronic absorption spectra, fluorescence spectroscopy, and cyclic voltammetry; cell viability (%) was assessed by absorbance measurement of the samples. RESULTS: The interaction mode of the complex A(3) with DNA is electrostatic, and this complex shows good potential in anticancer properties against HCT 116 (human colorectal cancer cells) and MDA-MB-231 (MD Anderson-metastatic breast) cell lines with 0.5 micromolar concentrations. CONCLUSION: The Ag(I) complex could interact with DNA noncovalently and has anticancer properties.

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