Cargando…

Integrated Gene Expression Profiling Analysis Reveals Probable Molecular Mechanism and Candidate Biomarker in Anti-TNFα Non-Response IBD Patients

PURPOSE: To explore the molecular mechanism and search for candidate biomarkers in the gene expression profile of IBD patients associated with the response to anti-TNFα agents. METHODS: Differentially expressed genes (DEGs) of response vs non-response IBD patients in datasets GSE12251, GSE16879, and...

Descripción completa

Detalles Bibliográficos
Autores principales:	Liu, Yifan, Duan, Yantao, Li, Yousheng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove 2020
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7024800/ https://www.ncbi.nlm.nih.gov/pubmed/32104045 http://dx.doi.org/10.2147/JIR.S236262

Ejemplares similares

Gene expression profiling reveals candidate biomarkers and probable molecular mechanisms in chronic stress
por: Zhang, Bohan, et al.
Publicado: (2022)

Cell-centred meta-analysis reveals baseline predictors of anti-TNFα non-response in biopsy and blood of patients with IBD
por: Gaujoux, Renaud, et al.
Publicado: (2019)

Gene expression profiling reveals candidate biomarkers and probable molecular mechanism in diabetic peripheral neuropathy
por: Zhou, Han, et al.
Publicado: (2019)

Serum TGF-β1 and CD14 Predicts Response to Anti-TNF-α Therapy in IBD
por: Coufal, Stepan, et al.
Publicado: (2023)

Genome-wide DNA methylation profiling reveals candidate biomarkers and probable molecular mechanism of metabolic syndrome
por: Baek, Su-Jin, et al.
Publicado: (2022)

Safety of TNF-α inhibitors during IBD pregnancy: a systematic review
por: Nielsen, Ole Haagen, et al.
Publicado: (2013)

Anti-TNFα therapy in IBD alters brain activity reflecting visceral sensory function and cognitive-affective biases
por: Gray, Marcus A., et al.
Publicado: (2018)

TNFα inhibitor induced lupus-like syndrome (TAILS) in a patient with IBD
por: LUPU, A., et al.
Publicado: (2014)

Previous Intestinal Resection Is Associated with Postoperative Complications in Crohn's Disease: A Cohort Study
por: Duan, Yantao, et al.
Publicado: (2020)

IL-23 Blockade in Anti-TNF Refractory IBD: From Mechanisms to Clinical Reality
por: Atreya, Raja, et al.
Publicado: (2022)

Fecal Microbiome Changes and Specific Anti-Bacterial Response in Patients with IBD during Anti-TNF Therapy
por: Schierova, Dagmar, et al.
Publicado: (2021)

Functional Molecular Network Analysis Enables Prediction of Response to Vedolizumab Therapy in Anti-TNF Refractory IBD Patients
por: Breidert, Matthias, et al.
Publicado: (2020)

Personalizing Treatment in IBD: Hype or Reality in 2020? Can We Predict Response to Anti-TNF?
por: Atreya, Raja, et al.
Publicado: (2020)

Anti-TNF- αtreatment-related pathways and biomarkers revealed by transcriptome analysis in Chinese psoriasis patients
por: Liu, Lunfei, et al.
Publicado: (2019)

Anti-TNF therapy in IBD exerts its therapeutic effect through macrophage IL-10 signalling
por: Koelink, Pim J, et al.
Publicado: (2020)

The Role of Low-Dose Oral Methotrexate in Increasing Anti-TNF Drug Levels and Reducing Immunogenicity in IBD
por: Demase, Kathryn, et al.
Publicado: (2023)

Integrative Clinical, Molecular, and Computational Analysis Identify Novel Biomarkers and Differential Profiles of Anti-TNF Response in Rheumatoid Arthritis
por: Luque-Tévar, Maria, et al.
Publicado: (2021)

Acute and probable chronic Q fever during anti-TNFα and anti B-cell immunotherapy: a case report
por: Schoffelen, Teske, et al.
Publicado: (2014)

Could Mucosal TNF Transcript as a Biomarker Candidate Help Optimize Anti-TNF Biological Therapy in Patients With Ulcerative Colitis?
por: Cui, Guanglin, et al.
Publicado: (2022)

Intestinal microbiota changes induced by TNF-inhibitors in IBD-related spondyloarthritis
por: Ditto, Maria Chiara, et al.
Publicado: (2021)

Assessment of Anti-TNF-α Activities in Keratinocytes Expressing Inducible TNF- α: A Novel Tool for Anti-TNF-α Drug Screening
por: Udommethaporn, Sutthirat, et al.
Publicado: (2016)

The Continental Divide: Anti-TNF Use in Pediatric IBD Is Different in North America Compared to Other Parts of the World
por: Church, Peter C., et al.
Publicado: (2018)

Skin microbiota signature distinguishes IBD patients and reflects skin adverse events during anti-TNF therapy
por: Reiss, Zuzana, et al.
Publicado: (2023)

Effect of vitamin D3 supplementation on TNF-α serum level and disease activity index in Iranian IBD patients
por: Dadaei, Tahereh, et al.
Publicado: (2015)

TNF-α/anti-TNF-α drugs and its effect on pregnancy outcomes
por: Dai, Fang-fang, et al.
Publicado: (2022)

Biomarkers in IBD: What to Utilize for the Diagnosis?
por: D’Incà, Renata, et al.
Publicado: (2023)

PIGS: improved estimates of identity-by-descent probabilities by probabilistic IBD graph sampling
por: Park, Danny S, et al.
Publicado: (2015)

The Role of TNF-α and Anti-TNF-α Agents during Preconception, Pregnancy, and Breastfeeding
por: Romanowska-Próchnicka, Katarzyna, et al.
Publicado: (2021)

Transmembrane TNF-α: structure, function and interaction with anti-TNF agents
por: Horiuchi, Takahiko, et al.
Publicado: (2010)

Effect of family relatedness on characteristics of estimated IBD probabilities in relation to precision of QTL estimates
por: Freyer, Gertraude, et al.
Publicado: (2010)

Integrated IBD Analysis, GWAS Analysis and Transcriptome Analysis to Identify the Candidate Genes for White Spot Disease in Maize
por: Wang, Dong, et al.
Publicado: (2023)

Blood and Intestine eQTLs from an Anti-TNF-Resistant Crohn's Disease Cohort Inform IBD Genetic Association Loci
por: Di Narzo, Antonio F, et al.
Publicado: (2016)

Monocyte TREM-1 Levels Associate With Anti-TNF Responsiveness in IBD Through Autophagy and Fcγ-Receptor Signaling Pathways
por: Prins, Marileen M., et al.
Publicado: (2021)

A blood-based prognostic biomarker in IBD
por: Biasci, Daniele, et al.
Publicado: (2019)

The Candidate IBD Risk Gene CCNY Is Dispensable for Intestinal Epithelial Homeostasis
por: Molinas, Andrea, et al.
Publicado: (2021)

Anti-TNF-α Therapy for Ankylosing Spondylitis
por: Son, Jung-Hwan, et al.
Publicado: (2010)

Anti-TNF-α therapy in membranous glomerulonephritis
por: Santoro, Domenico, et al.
Publicado: (2012)

COVID-19 Vaccine Booster Shot Preserves T Cells Immune Response Based on Interferon-Gamma Release Assay in Inflammatory Bowel Disease (IBD) Patients on Anti-TNFα Treatment
por: Pavia, Grazia, et al.
Publicado: (2023)

Molecular Landscape of Anti-Drug Antibodies Reveals the Mechanism of the Immune Response Following Treatment With TNFα Antagonists
por: Vaisman-Mentesh, Anna, et al.
Publicado: (2019)

Omics and Multi-Omics in IBD: No Integration, No Breakthroughs
por: Fiocchi, Claudio
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_bqchkbpnq6m6ud34kug1m1mrbg