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Prefoldin subunits (PFDN1–6) serve as poor prognostic markers in gastric cancer

Prefoldin subunits (PFDN), primarily known for co-chaperone function associated with cytoskeletal rearrangement, have been found involved in epithelial–mesenchymal transition (EMT) and cancer progression. However, studies focusing on the roles of PFDN in gastric cancer (GC) remain limited. The prese...

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Autores principales: Yesseyeva, Galiya, Aikemu, Batuer, Hong, Hiju, Yu, Chaoran, Dong, Feng, Sun, Jing, Zang, Lu, Zheng, Minhua, Ma, Junjun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7024841/
https://www.ncbi.nlm.nih.gov/pubmed/31957800
http://dx.doi.org/10.1042/BSR20192712
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author Yesseyeva, Galiya
Aikemu, Batuer
Hong, Hiju
Yu, Chaoran
Dong, Feng
Sun, Jing
Zang, Lu
Zheng, Minhua
Ma, Junjun
author_facet Yesseyeva, Galiya
Aikemu, Batuer
Hong, Hiju
Yu, Chaoran
Dong, Feng
Sun, Jing
Zang, Lu
Zheng, Minhua
Ma, Junjun
author_sort Yesseyeva, Galiya
collection PubMed
description Prefoldin subunits (PFDN), primarily known for co-chaperone function associated with cytoskeletal rearrangement, have been found involved in epithelial–mesenchymal transition (EMT) and cancer progression. However, studies focusing on the roles of PFDN in gastric cancer (GC) remain limited. The present study aims to evaluate the prognostic values of PFDN in GC. Prognostic roles of PFDNs were analyzed via the Kaplan–Meier platform, followed by subset analysis within various clinical parameters. High mRNA expression of PFDN2, PFDN3 and PFDN4 displayed poor overall survival (OS) while PFDN5 displayed favorable OS. In HER2+ subset, PFDN2, PFDN3, PFDN4 and PFDN6 displayed poor OS. In human epidermal growth factor receptor 2 (HER2−) subset, PFDN2, PFDN3 and PFDN4 displayed poor OS. In intestinal type subset, PFDN1 and PFDN2 displayed poor OS. In diffuse-type subset, PFDN2 and PFDN6 displayed poor OS. In moderate differentiation type subset, PFDN1 displayed poor OS. In poor differentiation type subset, PFDN2 and PFDN6 displayed poor OS. In metastasis negative subset, PFDN1, PFDN2 and PFDN6 displayed poor OS. In lymph node (LN) positive subset, PFDN2 and PFDN5 displayed poor OS. The present study provided insightful clues into the poor prognostic values of PFDNs in GC patients.
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spelling pubmed-70248412020-02-27 Prefoldin subunits (PFDN1–6) serve as poor prognostic markers in gastric cancer Yesseyeva, Galiya Aikemu, Batuer Hong, Hiju Yu, Chaoran Dong, Feng Sun, Jing Zang, Lu Zheng, Minhua Ma, Junjun Biosci Rep Bioinformatics Prefoldin subunits (PFDN), primarily known for co-chaperone function associated with cytoskeletal rearrangement, have been found involved in epithelial–mesenchymal transition (EMT) and cancer progression. However, studies focusing on the roles of PFDN in gastric cancer (GC) remain limited. The present study aims to evaluate the prognostic values of PFDN in GC. Prognostic roles of PFDNs were analyzed via the Kaplan–Meier platform, followed by subset analysis within various clinical parameters. High mRNA expression of PFDN2, PFDN3 and PFDN4 displayed poor overall survival (OS) while PFDN5 displayed favorable OS. In HER2+ subset, PFDN2, PFDN3, PFDN4 and PFDN6 displayed poor OS. In human epidermal growth factor receptor 2 (HER2−) subset, PFDN2, PFDN3 and PFDN4 displayed poor OS. In intestinal type subset, PFDN1 and PFDN2 displayed poor OS. In diffuse-type subset, PFDN2 and PFDN6 displayed poor OS. In moderate differentiation type subset, PFDN1 displayed poor OS. In poor differentiation type subset, PFDN2 and PFDN6 displayed poor OS. In metastasis negative subset, PFDN1, PFDN2 and PFDN6 displayed poor OS. In lymph node (LN) positive subset, PFDN2 and PFDN5 displayed poor OS. The present study provided insightful clues into the poor prognostic values of PFDNs in GC patients. Portland Press Ltd. 2020-02-14 /pmc/articles/PMC7024841/ /pubmed/31957800 http://dx.doi.org/10.1042/BSR20192712 Text en © 2020 The Author(s). https://creativecommons.org/licenses/by/4.0/ This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY).
spellingShingle Bioinformatics
Yesseyeva, Galiya
Aikemu, Batuer
Hong, Hiju
Yu, Chaoran
Dong, Feng
Sun, Jing
Zang, Lu
Zheng, Minhua
Ma, Junjun
Prefoldin subunits (PFDN1–6) serve as poor prognostic markers in gastric cancer
title Prefoldin subunits (PFDN1–6) serve as poor prognostic markers in gastric cancer
title_full Prefoldin subunits (PFDN1–6) serve as poor prognostic markers in gastric cancer
title_fullStr Prefoldin subunits (PFDN1–6) serve as poor prognostic markers in gastric cancer
title_full_unstemmed Prefoldin subunits (PFDN1–6) serve as poor prognostic markers in gastric cancer
title_short Prefoldin subunits (PFDN1–6) serve as poor prognostic markers in gastric cancer
title_sort prefoldin subunits (pfdn1–6) serve as poor prognostic markers in gastric cancer
topic Bioinformatics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7024841/
https://www.ncbi.nlm.nih.gov/pubmed/31957800
http://dx.doi.org/10.1042/BSR20192712
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