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Examining the functional activity of different obsessive–compulsive symptom dimensions in Tourette syndrome
OBJECTIVES: Tourette syndrome (TS) is commonly comorbid with obsessive–compulsive disorder (OCD) and many phenomenological similarities exist between tics and obsessive–compulsive symptoms (OCS). Therefore, due to the clinical importance of comorbid OCD, the goal of this study was to investigate the...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7025096/ https://www.ncbi.nlm.nih.gov/pubmed/32062563 http://dx.doi.org/10.1016/j.nicl.2020.102198 |
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author | Bhikram, Tracy Crawley, Adrian Arnold, Paul Abi-Jaoude, Elia Sandor, Paul |
author_facet | Bhikram, Tracy Crawley, Adrian Arnold, Paul Abi-Jaoude, Elia Sandor, Paul |
author_sort | Bhikram, Tracy |
collection | PubMed |
description | OBJECTIVES: Tourette syndrome (TS) is commonly comorbid with obsessive–compulsive disorder (OCD) and many phenomenological similarities exist between tics and obsessive–compulsive symptoms (OCS). Therefore, due to the clinical importance of comorbid OCD, the goal of this study was to investigate the neural substrates of OCS in TS using functional magnetic resonance imaging. METHODS: Forty patients with TS and 20 healthy controls underwent functional magnetic resonance imaging while viewing blocks of OCS-provoking pictures relating to washing, checking and symmetry symptoms, as well as generally disgusting and neutral scenes. Statistical comparisons were made between patients with moderate/severe OCS, absent/mild OCS and healthy controls. As well, within the entire TS patient group, significant associations with clinical measures were assessed for each of the provocation conditions. RESULTS: Group differences in the insula, sensorimotor cortex, supramarginal gyrus and visual processing regions were common among the checking, washing and disgust conditions. In the patient group, negative associations between OCS severity and activity in the supramarginal gyrus, inferior frontal gyrus, sensorimotor cortex, precuneus and visual processing regions were common among the provocation conditions. Tic severity was only associated with activity in the anterior cingulate cortex for the symmetry condition. CONCLUSION: Our findings implicate areas previously reported to be involved in OCD, as well as areas not typically implicated in OCD, suggesting that the neurobiological profile of TS+OCD is intermediate to pure TS and pure OCD. |
format | Online Article Text |
id | pubmed-7025096 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-70250962020-02-20 Examining the functional activity of different obsessive–compulsive symptom dimensions in Tourette syndrome Bhikram, Tracy Crawley, Adrian Arnold, Paul Abi-Jaoude, Elia Sandor, Paul Neuroimage Clin Regular Article OBJECTIVES: Tourette syndrome (TS) is commonly comorbid with obsessive–compulsive disorder (OCD) and many phenomenological similarities exist between tics and obsessive–compulsive symptoms (OCS). Therefore, due to the clinical importance of comorbid OCD, the goal of this study was to investigate the neural substrates of OCS in TS using functional magnetic resonance imaging. METHODS: Forty patients with TS and 20 healthy controls underwent functional magnetic resonance imaging while viewing blocks of OCS-provoking pictures relating to washing, checking and symmetry symptoms, as well as generally disgusting and neutral scenes. Statistical comparisons were made between patients with moderate/severe OCS, absent/mild OCS and healthy controls. As well, within the entire TS patient group, significant associations with clinical measures were assessed for each of the provocation conditions. RESULTS: Group differences in the insula, sensorimotor cortex, supramarginal gyrus and visual processing regions were common among the checking, washing and disgust conditions. In the patient group, negative associations between OCS severity and activity in the supramarginal gyrus, inferior frontal gyrus, sensorimotor cortex, precuneus and visual processing regions were common among the provocation conditions. Tic severity was only associated with activity in the anterior cingulate cortex for the symmetry condition. CONCLUSION: Our findings implicate areas previously reported to be involved in OCD, as well as areas not typically implicated in OCD, suggesting that the neurobiological profile of TS+OCD is intermediate to pure TS and pure OCD. Elsevier 2020-01-25 /pmc/articles/PMC7025096/ /pubmed/32062563 http://dx.doi.org/10.1016/j.nicl.2020.102198 Text en © 2020 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Regular Article Bhikram, Tracy Crawley, Adrian Arnold, Paul Abi-Jaoude, Elia Sandor, Paul Examining the functional activity of different obsessive–compulsive symptom dimensions in Tourette syndrome |
title | Examining the functional activity of different obsessive–compulsive symptom dimensions in Tourette syndrome |
title_full | Examining the functional activity of different obsessive–compulsive symptom dimensions in Tourette syndrome |
title_fullStr | Examining the functional activity of different obsessive–compulsive symptom dimensions in Tourette syndrome |
title_full_unstemmed | Examining the functional activity of different obsessive–compulsive symptom dimensions in Tourette syndrome |
title_short | Examining the functional activity of different obsessive–compulsive symptom dimensions in Tourette syndrome |
title_sort | examining the functional activity of different obsessive–compulsive symptom dimensions in tourette syndrome |
topic | Regular Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7025096/ https://www.ncbi.nlm.nih.gov/pubmed/32062563 http://dx.doi.org/10.1016/j.nicl.2020.102198 |
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