A new expression of immune checkpoint inhibitors’ renal toxicity: when distal tubular acidosis precedes creatinine elevation

The main manifestation of acute interstitial nephritis (AIN) due to immune checkpoint inhibitors is acute kidney injury. We report here a biopsy-proven AIN revealed by tubular acidosis. This case highlights that immune checkpoint inhibitor prescribers must be aware of electrolytic disorders since tu...

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Autores principales: Charmetant, Xavier, Teuma, Cécile, Lake, Jennifer, Dijoud, Frédérique, Frochot, Vincent, Deeb, Abbas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Onconephrology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7025331/
https://www.ncbi.nlm.nih.gov/pubmed/32082551
http://dx.doi.org/10.1093/ckj/sfz051
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author Charmetant, Xavier
Teuma, Cécile
Lake, Jennifer
Dijoud, Frédérique
Frochot, Vincent
Deeb, Abbas
author_facet Charmetant, Xavier
Teuma, Cécile
Lake, Jennifer
Dijoud, Frédérique
Frochot, Vincent
Deeb, Abbas
author_sort Charmetant, Xavier
collection PubMed
description The main manifestation of acute interstitial nephritis (AIN) due to immune checkpoint inhibitors is acute kidney injury. We report here a biopsy-proven AIN revealed by tubular acidosis. This case highlights that immune checkpoint inhibitor prescribers must be aware of electrolytic disorders since tubular dysfunction can precede serum creatinine increase and reveal renal toxicity.
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spelling pubmed-70253312020-02-20 A new expression of immune checkpoint inhibitors’ renal toxicity: when distal tubular acidosis precedes creatinine elevation Charmetant, Xavier Teuma, Cécile Lake, Jennifer Dijoud, Frédérique Frochot, Vincent Deeb, Abbas Clin Kidney J Onconephrology The main manifestation of acute interstitial nephritis (AIN) due to immune checkpoint inhibitors is acute kidney injury. We report here a biopsy-proven AIN revealed by tubular acidosis. This case highlights that immune checkpoint inhibitor prescribers must be aware of electrolytic disorders since tubular dysfunction can precede serum creatinine increase and reveal renal toxicity. Oxford University Press 2019-05-14 /pmc/articles/PMC7025331/ /pubmed/32082551 http://dx.doi.org/10.1093/ckj/sfz051 Text en © The Author(s) 2019. Published by Oxford University Press on behalf of ERA-EDTA. http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Onconephrology
Charmetant, Xavier
Teuma, Cécile
Lake, Jennifer
Dijoud, Frédérique
Frochot, Vincent
Deeb, Abbas
A new expression of immune checkpoint inhibitors’ renal toxicity: when distal tubular acidosis precedes creatinine elevation
title A new expression of immune checkpoint inhibitors’ renal toxicity: when distal tubular acidosis precedes creatinine elevation
title_full A new expression of immune checkpoint inhibitors’ renal toxicity: when distal tubular acidosis precedes creatinine elevation
title_fullStr A new expression of immune checkpoint inhibitors’ renal toxicity: when distal tubular acidosis precedes creatinine elevation
title_full_unstemmed A new expression of immune checkpoint inhibitors’ renal toxicity: when distal tubular acidosis precedes creatinine elevation
title_short A new expression of immune checkpoint inhibitors’ renal toxicity: when distal tubular acidosis precedes creatinine elevation
title_sort new expression of immune checkpoint inhibitors’ renal toxicity: when distal tubular acidosis precedes creatinine elevation
topic Onconephrology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7025331/
https://www.ncbi.nlm.nih.gov/pubmed/32082551
http://dx.doi.org/10.1093/ckj/sfz051
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