α-Helix-Mimicking Sulfono-γ-AApeptide Inhibitors for p53–MDM2/MDMX Protein–Protein Interactions

[Image: see text] The use of peptidomimetic scaffolds is a promising strategy for the inhibition of protein–protein interactions (PPIs). Herein, we demonstrate that sulfono-γ-AApeptides can be rationally designed to mimic the p53 α-helix and inhibit p53–MDM2 PPIs. The best inhibitor, with K(d) and I...

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Detalles Bibliográficos
Autores principales: Sang, Peng, Shi, Yan, Lu, Junhao, Chen, Lihong, Yang, Leixiang, Borcherds, Wade, Abdulkadir, Sami, Li, Qi, Daughdrill, Gary, Chen, Jiandong, Cai, Jianfeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2020
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7025332/
https://www.ncbi.nlm.nih.gov/pubmed/31971801
http://dx.doi.org/10.1021/acs.jmedchem.9b00993

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