Acute kidney injury in an infant of a kidney allograft recipient

Tacrolimus has been used in pregnant organ recipients for >20 years, and the relationship between fetal complications and the amount of tacrolimus crossing the placenta is still controversial. We report the case of a kidney transplant recipient who used tacrolimus and gave birth to an offspring t...

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Autores principales: Aktürk, Serkan, Sadioğlu, Rezzan Eren, Şengül, Şule, Keven, Kenan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Transplantation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7025340/
https://www.ncbi.nlm.nih.gov/pubmed/32082563
http://dx.doi.org/10.1093/ckj/sfz093
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author Aktürk, Serkan
Sadioğlu, Rezzan Eren
Şengül, Şule
Keven, Kenan
author_facet Aktürk, Serkan
Sadioğlu, Rezzan Eren
Şengül, Şule
Keven, Kenan
author_sort Aktürk, Serkan
collection PubMed
description Tacrolimus has been used in pregnant organ recipients for >20 years, and the relationship between fetal complications and the amount of tacrolimus crossing the placenta is still controversial. We report the case of a kidney transplant recipient who used tacrolimus and gave birth to an offspring that developed, shortly after birth, an acute kidney injury caused by tacrolimus exposure, which was detected by measuring tacrolimus levels in the umbilical vein, as well as in maternal blood. Even if whole‐blood levels of tacrolimus are within the therapeutic range throughout pregnancy, the amount of tacrolimus could reach toxic levels.
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spelling pubmed-70253402020-02-20 Acute kidney injury in an infant of a kidney allograft recipient Aktürk, Serkan Sadioğlu, Rezzan Eren Şengül, Şule Keven, Kenan Clin Kidney J Transplantation Tacrolimus has been used in pregnant organ recipients for >20 years, and the relationship between fetal complications and the amount of tacrolimus crossing the placenta is still controversial. We report the case of a kidney transplant recipient who used tacrolimus and gave birth to an offspring that developed, shortly after birth, an acute kidney injury caused by tacrolimus exposure, which was detected by measuring tacrolimus levels in the umbilical vein, as well as in maternal blood. Even if whole‐blood levels of tacrolimus are within the therapeutic range throughout pregnancy, the amount of tacrolimus could reach toxic levels. Oxford University Press 2019-08-08 /pmc/articles/PMC7025340/ /pubmed/32082563 http://dx.doi.org/10.1093/ckj/sfz093 Text en © The Author(s) 2019. Published by Oxford University Press on behalf of ERA-EDTA. http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Transplantation
Aktürk, Serkan
Sadioğlu, Rezzan Eren
Şengül, Şule
Keven, Kenan
Acute kidney injury in an infant of a kidney allograft recipient
title Acute kidney injury in an infant of a kidney allograft recipient
title_full Acute kidney injury in an infant of a kidney allograft recipient
title_fullStr Acute kidney injury in an infant of a kidney allograft recipient
title_full_unstemmed Acute kidney injury in an infant of a kidney allograft recipient
title_short Acute kidney injury in an infant of a kidney allograft recipient
title_sort acute kidney injury in an infant of a kidney allograft recipient
topic Transplantation
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7025340/
https://www.ncbi.nlm.nih.gov/pubmed/32082563
http://dx.doi.org/10.1093/ckj/sfz093
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AT sengulsule acutekidneyinjuryinaninfantofakidneyallograftrecipient
AT kevenkenan acutekidneyinjuryinaninfantofakidneyallograftrecipient

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