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Predictive Value of Uric Acid Regarding Cardiometabolic Disease in a Community-Dwelling Older Population in Shanghai: A Cohort Study
Aim: This study aimed to test the predictive power of serum uric acid (UA) levels on new-onset cardiometabolic risk in the Chinese population. Methods: Older people who visited a community health center for a yearly health check (N = 5,000; men: 47%, women: 53%) were enrolled. Participants were foll...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7025523/ https://www.ncbi.nlm.nih.gov/pubmed/32118009 http://dx.doi.org/10.3389/fmed.2020.00024 |
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author | Lan, Qin Wu, Hong Zhou, Xiaohui Zheng, Liang Lin, Fang Meng, Qingshu Xi, Xiaoling Yue, Aixue Buys, Nicholas Sun, Jing Liu, Zhongmin Li, Jue Fan, Huimin |
author_facet | Lan, Qin Wu, Hong Zhou, Xiaohui Zheng, Liang Lin, Fang Meng, Qingshu Xi, Xiaoling Yue, Aixue Buys, Nicholas Sun, Jing Liu, Zhongmin Li, Jue Fan, Huimin |
author_sort | Lan, Qin |
collection | PubMed |
description | Aim: This study aimed to test the predictive power of serum uric acid (UA) levels on new-onset cardiometabolic risk in the Chinese population. Methods: Older people who visited a community health center for a yearly health check (N = 5,000; men: 47%, women: 53%) were enrolled. Participants were followed for 4 years from baseline (median: 48 months), with the endpoints being development of heart failure, atrial fibrillation, diabetes, hypertension, metabolic syndrome, or kidney disease. Results: During follow-up, 342 men (7.4%) and 360 women (8.6%) developed hypertension; 98 men (2.48%) and 135 women (3.06%) developed diabetes; and 175 men (5.04%) and 214 women (4.51%) developed metabolic syndrome. Incident diabetes, hypertension, and metabolic syndrome increased with increased UA levels at baseline (P < 0.001). A multivariate Cox proportional hazards analysis revealed a significant, independent association between the baseline UA level and the onset and future hypertension and/or diabetes in both men and women. However, UA is associated with the development of metabolic syndrome in men, but not in women. Conclusion: UA is an independent predictor of new-onset diabetes and hypertension in both women and men and a predictor of new-onset metabolic syndrome only in men. |
format | Online Article Text |
id | pubmed-7025523 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-70255232020-02-28 Predictive Value of Uric Acid Regarding Cardiometabolic Disease in a Community-Dwelling Older Population in Shanghai: A Cohort Study Lan, Qin Wu, Hong Zhou, Xiaohui Zheng, Liang Lin, Fang Meng, Qingshu Xi, Xiaoling Yue, Aixue Buys, Nicholas Sun, Jing Liu, Zhongmin Li, Jue Fan, Huimin Front Med (Lausanne) Medicine Aim: This study aimed to test the predictive power of serum uric acid (UA) levels on new-onset cardiometabolic risk in the Chinese population. Methods: Older people who visited a community health center for a yearly health check (N = 5,000; men: 47%, women: 53%) were enrolled. Participants were followed for 4 years from baseline (median: 48 months), with the endpoints being development of heart failure, atrial fibrillation, diabetes, hypertension, metabolic syndrome, or kidney disease. Results: During follow-up, 342 men (7.4%) and 360 women (8.6%) developed hypertension; 98 men (2.48%) and 135 women (3.06%) developed diabetes; and 175 men (5.04%) and 214 women (4.51%) developed metabolic syndrome. Incident diabetes, hypertension, and metabolic syndrome increased with increased UA levels at baseline (P < 0.001). A multivariate Cox proportional hazards analysis revealed a significant, independent association between the baseline UA level and the onset and future hypertension and/or diabetes in both men and women. However, UA is associated with the development of metabolic syndrome in men, but not in women. Conclusion: UA is an independent predictor of new-onset diabetes and hypertension in both women and men and a predictor of new-onset metabolic syndrome only in men. Frontiers Media S.A. 2020-02-05 /pmc/articles/PMC7025523/ /pubmed/32118009 http://dx.doi.org/10.3389/fmed.2020.00024 Text en Copyright © 2020 Lan, Wu, Zhou, Zheng, Lin, Meng, Xi, Yue, Buys, Sun, Liu, Li and Fan. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Medicine Lan, Qin Wu, Hong Zhou, Xiaohui Zheng, Liang Lin, Fang Meng, Qingshu Xi, Xiaoling Yue, Aixue Buys, Nicholas Sun, Jing Liu, Zhongmin Li, Jue Fan, Huimin Predictive Value of Uric Acid Regarding Cardiometabolic Disease in a Community-Dwelling Older Population in Shanghai: A Cohort Study |
title | Predictive Value of Uric Acid Regarding Cardiometabolic Disease in a Community-Dwelling Older Population in Shanghai: A Cohort Study |
title_full | Predictive Value of Uric Acid Regarding Cardiometabolic Disease in a Community-Dwelling Older Population in Shanghai: A Cohort Study |
title_fullStr | Predictive Value of Uric Acid Regarding Cardiometabolic Disease in a Community-Dwelling Older Population in Shanghai: A Cohort Study |
title_full_unstemmed | Predictive Value of Uric Acid Regarding Cardiometabolic Disease in a Community-Dwelling Older Population in Shanghai: A Cohort Study |
title_short | Predictive Value of Uric Acid Regarding Cardiometabolic Disease in a Community-Dwelling Older Population in Shanghai: A Cohort Study |
title_sort | predictive value of uric acid regarding cardiometabolic disease in a community-dwelling older population in shanghai: a cohort study |
topic | Medicine |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7025523/ https://www.ncbi.nlm.nih.gov/pubmed/32118009 http://dx.doi.org/10.3389/fmed.2020.00024 |
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