Cargando…

Predictive Value of Uric Acid Regarding Cardiometabolic Disease in a Community-Dwelling Older Population in Shanghai: A Cohort Study

Aim: This study aimed to test the predictive power of serum uric acid (UA) levels on new-onset cardiometabolic risk in the Chinese population. Methods: Older people who visited a community health center for a yearly health check (N = 5,000; men: 47%, women: 53%) were enrolled. Participants were foll...

Descripción completa

Detalles Bibliográficos
Autores principales: Lan, Qin, Wu, Hong, Zhou, Xiaohui, Zheng, Liang, Lin, Fang, Meng, Qingshu, Xi, Xiaoling, Yue, Aixue, Buys, Nicholas, Sun, Jing, Liu, Zhongmin, Li, Jue, Fan, Huimin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7025523/
https://www.ncbi.nlm.nih.gov/pubmed/32118009
http://dx.doi.org/10.3389/fmed.2020.00024
_version_ 1783498528164675584
author Lan, Qin
Wu, Hong
Zhou, Xiaohui
Zheng, Liang
Lin, Fang
Meng, Qingshu
Xi, Xiaoling
Yue, Aixue
Buys, Nicholas
Sun, Jing
Liu, Zhongmin
Li, Jue
Fan, Huimin
author_facet Lan, Qin
Wu, Hong
Zhou, Xiaohui
Zheng, Liang
Lin, Fang
Meng, Qingshu
Xi, Xiaoling
Yue, Aixue
Buys, Nicholas
Sun, Jing
Liu, Zhongmin
Li, Jue
Fan, Huimin
author_sort Lan, Qin
collection PubMed
description Aim: This study aimed to test the predictive power of serum uric acid (UA) levels on new-onset cardiometabolic risk in the Chinese population. Methods: Older people who visited a community health center for a yearly health check (N = 5,000; men: 47%, women: 53%) were enrolled. Participants were followed for 4 years from baseline (median: 48 months), with the endpoints being development of heart failure, atrial fibrillation, diabetes, hypertension, metabolic syndrome, or kidney disease. Results: During follow-up, 342 men (7.4%) and 360 women (8.6%) developed hypertension; 98 men (2.48%) and 135 women (3.06%) developed diabetes; and 175 men (5.04%) and 214 women (4.51%) developed metabolic syndrome. Incident diabetes, hypertension, and metabolic syndrome increased with increased UA levels at baseline (P < 0.001). A multivariate Cox proportional hazards analysis revealed a significant, independent association between the baseline UA level and the onset and future hypertension and/or diabetes in both men and women. However, UA is associated with the development of metabolic syndrome in men, but not in women. Conclusion: UA is an independent predictor of new-onset diabetes and hypertension in both women and men and a predictor of new-onset metabolic syndrome only in men.
format Online
Article
Text
id pubmed-7025523
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-70255232020-02-28 Predictive Value of Uric Acid Regarding Cardiometabolic Disease in a Community-Dwelling Older Population in Shanghai: A Cohort Study Lan, Qin Wu, Hong Zhou, Xiaohui Zheng, Liang Lin, Fang Meng, Qingshu Xi, Xiaoling Yue, Aixue Buys, Nicholas Sun, Jing Liu, Zhongmin Li, Jue Fan, Huimin Front Med (Lausanne) Medicine Aim: This study aimed to test the predictive power of serum uric acid (UA) levels on new-onset cardiometabolic risk in the Chinese population. Methods: Older people who visited a community health center for a yearly health check (N = 5,000; men: 47%, women: 53%) were enrolled. Participants were followed for 4 years from baseline (median: 48 months), with the endpoints being development of heart failure, atrial fibrillation, diabetes, hypertension, metabolic syndrome, or kidney disease. Results: During follow-up, 342 men (7.4%) and 360 women (8.6%) developed hypertension; 98 men (2.48%) and 135 women (3.06%) developed diabetes; and 175 men (5.04%) and 214 women (4.51%) developed metabolic syndrome. Incident diabetes, hypertension, and metabolic syndrome increased with increased UA levels at baseline (P < 0.001). A multivariate Cox proportional hazards analysis revealed a significant, independent association between the baseline UA level and the onset and future hypertension and/or diabetes in both men and women. However, UA is associated with the development of metabolic syndrome in men, but not in women. Conclusion: UA is an independent predictor of new-onset diabetes and hypertension in both women and men and a predictor of new-onset metabolic syndrome only in men. Frontiers Media S.A. 2020-02-05 /pmc/articles/PMC7025523/ /pubmed/32118009 http://dx.doi.org/10.3389/fmed.2020.00024 Text en Copyright © 2020 Lan, Wu, Zhou, Zheng, Lin, Meng, Xi, Yue, Buys, Sun, Liu, Li and Fan. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Medicine
Lan, Qin
Wu, Hong
Zhou, Xiaohui
Zheng, Liang
Lin, Fang
Meng, Qingshu
Xi, Xiaoling
Yue, Aixue
Buys, Nicholas
Sun, Jing
Liu, Zhongmin
Li, Jue
Fan, Huimin
Predictive Value of Uric Acid Regarding Cardiometabolic Disease in a Community-Dwelling Older Population in Shanghai: A Cohort Study
title Predictive Value of Uric Acid Regarding Cardiometabolic Disease in a Community-Dwelling Older Population in Shanghai: A Cohort Study
title_full Predictive Value of Uric Acid Regarding Cardiometabolic Disease in a Community-Dwelling Older Population in Shanghai: A Cohort Study
title_fullStr Predictive Value of Uric Acid Regarding Cardiometabolic Disease in a Community-Dwelling Older Population in Shanghai: A Cohort Study
title_full_unstemmed Predictive Value of Uric Acid Regarding Cardiometabolic Disease in a Community-Dwelling Older Population in Shanghai: A Cohort Study
title_short Predictive Value of Uric Acid Regarding Cardiometabolic Disease in a Community-Dwelling Older Population in Shanghai: A Cohort Study
title_sort predictive value of uric acid regarding cardiometabolic disease in a community-dwelling older population in shanghai: a cohort study
topic Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7025523/
https://www.ncbi.nlm.nih.gov/pubmed/32118009
http://dx.doi.org/10.3389/fmed.2020.00024
work_keys_str_mv AT lanqin predictivevalueofuricacidregardingcardiometabolicdiseaseinacommunitydwellingolderpopulationinshanghaiacohortstudy
AT wuhong predictivevalueofuricacidregardingcardiometabolicdiseaseinacommunitydwellingolderpopulationinshanghaiacohortstudy
AT zhouxiaohui predictivevalueofuricacidregardingcardiometabolicdiseaseinacommunitydwellingolderpopulationinshanghaiacohortstudy
AT zhengliang predictivevalueofuricacidregardingcardiometabolicdiseaseinacommunitydwellingolderpopulationinshanghaiacohortstudy
AT linfang predictivevalueofuricacidregardingcardiometabolicdiseaseinacommunitydwellingolderpopulationinshanghaiacohortstudy
AT mengqingshu predictivevalueofuricacidregardingcardiometabolicdiseaseinacommunitydwellingolderpopulationinshanghaiacohortstudy
AT xixiaoling predictivevalueofuricacidregardingcardiometabolicdiseaseinacommunitydwellingolderpopulationinshanghaiacohortstudy
AT yueaixue predictivevalueofuricacidregardingcardiometabolicdiseaseinacommunitydwellingolderpopulationinshanghaiacohortstudy
AT buysnicholas predictivevalueofuricacidregardingcardiometabolicdiseaseinacommunitydwellingolderpopulationinshanghaiacohortstudy
AT sunjing predictivevalueofuricacidregardingcardiometabolicdiseaseinacommunitydwellingolderpopulationinshanghaiacohortstudy
AT liuzhongmin predictivevalueofuricacidregardingcardiometabolicdiseaseinacommunitydwellingolderpopulationinshanghaiacohortstudy
AT lijue predictivevalueofuricacidregardingcardiometabolicdiseaseinacommunitydwellingolderpopulationinshanghaiacohortstudy
AT fanhuimin predictivevalueofuricacidregardingcardiometabolicdiseaseinacommunitydwellingolderpopulationinshanghaiacohortstudy