High Cytotoxic Efficiency of Lentivirally and Alpharetrovirally Engineered CD19-Specific Chimeric Antigen Receptor Natural Killer Cells Against Acute Lymphoblastic Leukemia

Autologous chimeric antigen receptor-modified (CAR) T cells with specificity for CD19 showed potent antitumor efficacy in clinical trials against relapsed and refractory B-cell acute lymphoblastic leukemia (B-ALL). Contrary to T cells, natural killer (NK) cells kill their targets in a non-antigen-sp...

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Detalles Bibliográficos
Autores principales: Müller, Stephan, Bexte, Tobias, Gebel, Veronika, Kalensee, Franziska, Stolzenberg, Eva, Hartmann, Jessica, Koehl, Ulrike, Schambach, Axel, Wels, Winfried S., Modlich, Ute, Ullrich, Evelyn
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7025537/
https://www.ncbi.nlm.nih.gov/pubmed/32117200
http://dx.doi.org/10.3389/fimmu.2019.03123

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7025537/
https://www.ncbi.nlm.nih.gov/pubmed/32117200
http://dx.doi.org/10.3389/fimmu.2019.03123

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