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Growth hormone in the tumor microenvironment
Tumor development is a multistep process whereby local mechanisms enable somatic mutations during preneoplastic stages. Once a tumor develops, it becomes a complex organ composed of multiple cell types. Interactions between malignant and non-transformed cells and tissues create a tumor microenvironm...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Sociedade Brasileira de Endocrinologia e Metabologia
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7025769/ https://www.ncbi.nlm.nih.gov/pubmed/31939481 http://dx.doi.org/10.20945/2359-3997000000186 |
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author | Chesnokova, Vera Melmed, Shlomo |
author_facet | Chesnokova, Vera Melmed, Shlomo |
author_sort | Chesnokova, Vera |
collection | PubMed |
description | Tumor development is a multistep process whereby local mechanisms enable somatic mutations during preneoplastic stages. Once a tumor develops, it becomes a complex organ composed of multiple cell types. Interactions between malignant and non-transformed cells and tissues create a tumor microenvironment (TME) comprising epithelial cancer cells, cancer stem cells, non-tumorous cells, stromal cells, immune-inflammatory cells, blood and lymphatic vascular network, and extracellular matrix. We review reports and present a hypothesis that postulates the involvement of growth hormone (GH) in field cancerization. We discuss GH contribution to TME, promoting epithelial-to-mesenchymal transition, accumulation of unrepaired DNA damage, tumor vascularity, and resistance to therapy. Arch Endocrinol Metab. 2019;63(6):568-75 |
format | Online Article Text |
id | pubmed-7025769 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Sociedade Brasileira de Endocrinologia e Metabologia |
record_format | MEDLINE/PubMed |
spelling | pubmed-70257692020-02-17 Growth hormone in the tumor microenvironment Chesnokova, Vera Melmed, Shlomo Arch Endocrinol Metab Review Tumor development is a multistep process whereby local mechanisms enable somatic mutations during preneoplastic stages. Once a tumor develops, it becomes a complex organ composed of multiple cell types. Interactions between malignant and non-transformed cells and tissues create a tumor microenvironment (TME) comprising epithelial cancer cells, cancer stem cells, non-tumorous cells, stromal cells, immune-inflammatory cells, blood and lymphatic vascular network, and extracellular matrix. We review reports and present a hypothesis that postulates the involvement of growth hormone (GH) in field cancerization. We discuss GH contribution to TME, promoting epithelial-to-mesenchymal transition, accumulation of unrepaired DNA damage, tumor vascularity, and resistance to therapy. Arch Endocrinol Metab. 2019;63(6):568-75 Sociedade Brasileira de Endocrinologia e Metabologia 2019-11-01 /pmc/articles/PMC7025769/ /pubmed/31939481 http://dx.doi.org/10.20945/2359-3997000000186 Text en https://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Chesnokova, Vera Melmed, Shlomo Growth hormone in the tumor microenvironment |
title | Growth hormone in the tumor microenvironment |
title_full | Growth hormone in the tumor microenvironment |
title_fullStr | Growth hormone in the tumor microenvironment |
title_full_unstemmed | Growth hormone in the tumor microenvironment |
title_short | Growth hormone in the tumor microenvironment |
title_sort | growth hormone in the tumor microenvironment |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7025769/ https://www.ncbi.nlm.nih.gov/pubmed/31939481 http://dx.doi.org/10.20945/2359-3997000000186 |
work_keys_str_mv | AT chesnokovavera growthhormoneinthetumormicroenvironment AT melmedshlomo growthhormoneinthetumormicroenvironment |