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Growth hormone in the tumor microenvironment

Tumor development is a multistep process whereby local mechanisms enable somatic mutations during preneoplastic stages. Once a tumor develops, it becomes a complex organ composed of multiple cell types. Interactions between malignant and non-transformed cells and tissues create a tumor microenvironm...

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Detalles Bibliográficos
Autores principales: Chesnokova, Vera, Melmed, Shlomo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sociedade Brasileira de Endocrinologia e Metabologia 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7025769/
https://www.ncbi.nlm.nih.gov/pubmed/31939481
http://dx.doi.org/10.20945/2359-3997000000186
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author Chesnokova, Vera
Melmed, Shlomo
author_facet Chesnokova, Vera
Melmed, Shlomo
author_sort Chesnokova, Vera
collection PubMed
description Tumor development is a multistep process whereby local mechanisms enable somatic mutations during preneoplastic stages. Once a tumor develops, it becomes a complex organ composed of multiple cell types. Interactions between malignant and non-transformed cells and tissues create a tumor microenvironment (TME) comprising epithelial cancer cells, cancer stem cells, non-tumorous cells, stromal cells, immune-inflammatory cells, blood and lymphatic vascular network, and extracellular matrix. We review reports and present a hypothesis that postulates the involvement of growth hormone (GH) in field cancerization. We discuss GH contribution to TME, promoting epithelial-to-mesenchymal transition, accumulation of unrepaired DNA damage, tumor vascularity, and resistance to therapy. Arch Endocrinol Metab. 2019;63(6):568-75
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spelling pubmed-70257692020-02-17 Growth hormone in the tumor microenvironment Chesnokova, Vera Melmed, Shlomo Arch Endocrinol Metab Review Tumor development is a multistep process whereby local mechanisms enable somatic mutations during preneoplastic stages. Once a tumor develops, it becomes a complex organ composed of multiple cell types. Interactions between malignant and non-transformed cells and tissues create a tumor microenvironment (TME) comprising epithelial cancer cells, cancer stem cells, non-tumorous cells, stromal cells, immune-inflammatory cells, blood and lymphatic vascular network, and extracellular matrix. We review reports and present a hypothesis that postulates the involvement of growth hormone (GH) in field cancerization. We discuss GH contribution to TME, promoting epithelial-to-mesenchymal transition, accumulation of unrepaired DNA damage, tumor vascularity, and resistance to therapy. Arch Endocrinol Metab. 2019;63(6):568-75 Sociedade Brasileira de Endocrinologia e Metabologia 2019-11-01 /pmc/articles/PMC7025769/ /pubmed/31939481 http://dx.doi.org/10.20945/2359-3997000000186 Text en https://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Chesnokova, Vera
Melmed, Shlomo
Growth hormone in the tumor microenvironment
title Growth hormone in the tumor microenvironment
title_full Growth hormone in the tumor microenvironment
title_fullStr Growth hormone in the tumor microenvironment
title_full_unstemmed Growth hormone in the tumor microenvironment
title_short Growth hormone in the tumor microenvironment
title_sort growth hormone in the tumor microenvironment
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7025769/
https://www.ncbi.nlm.nih.gov/pubmed/31939481
http://dx.doi.org/10.20945/2359-3997000000186
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