The Proteolytic Cleavage of Therapeutic Monoclonal Antibody Hinge Region: More Than a Matter of Subclass

The hinge region of immunoglobulin G (IgG) is involved in C1q and FcγRIIIA-expressing natural killer (NK) cell recruitment. Both heavy chains (HCs) of the hinge region can be cleaved sequentially by several proteases of the tumor/inflammatory/infectious microenvironment, including matrix metalloprot...

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Detalles Bibliográficos
Autores principales: Deveuve, Quentin, Lajoie, Laurie, Barrault, Benjamin, Thibault, Gilles
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7026020/
https://www.ncbi.nlm.nih.gov/pubmed/32117299
http://dx.doi.org/10.3389/fimmu.2020.00168

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7026020/
https://www.ncbi.nlm.nih.gov/pubmed/32117299
http://dx.doi.org/10.3389/fimmu.2020.00168

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