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The Proteolytic Cleavage of Therapeutic Monoclonal Antibody Hinge Region: More Than a Matter of Subclass
The hinge region of immunoglobulin G (IgG) is involved in C1q and FcγRIIIA-expressing natural killer (NK) cell recruitment. Both heavy chains (HCs) of the hinge region can be cleaved sequentially by several proteases of the tumor/inflammatory/infectious microenvironment, including matrix metalloprot...
Autores principales: | Deveuve, Quentin, Lajoie, Laurie, Barrault, Benjamin, Thibault, Gilles |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7026020/ https://www.ncbi.nlm.nih.gov/pubmed/32117299 http://dx.doi.org/10.3389/fimmu.2020.00168 |
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