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Delayed sleep timing and circadian rhythms in pregnancy and transdiagnostic symptoms associated with postpartum depression

Later sleep timing, circadian preference, and circadian rhythm timing predict worse outcomes across multiple domains, including mood disorders, substance use, impulse control, and cognitive function. Disturbed sleep is common among pregnant and postpartum women. We examined whether sleep timing duri...

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Autores principales: Obeysekare, Jessica L., Cohen, Zachary L., Coles, Meredith E., Pearlstein, Teri B., Monzon, Carmen, Flynn, E. Ellen, Sharkey, Katherine M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7026062/
https://www.ncbi.nlm.nih.gov/pubmed/32066689
http://dx.doi.org/10.1038/s41398-020-0683-3
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author Obeysekare, Jessica L.
Cohen, Zachary L.
Coles, Meredith E.
Pearlstein, Teri B.
Monzon, Carmen
Flynn, E. Ellen
Sharkey, Katherine M.
author_facet Obeysekare, Jessica L.
Cohen, Zachary L.
Coles, Meredith E.
Pearlstein, Teri B.
Monzon, Carmen
Flynn, E. Ellen
Sharkey, Katherine M.
author_sort Obeysekare, Jessica L.
collection PubMed
description Later sleep timing, circadian preference, and circadian rhythm timing predict worse outcomes across multiple domains, including mood disorders, substance use, impulse control, and cognitive function. Disturbed sleep is common among pregnant and postpartum women. We examined whether sleep timing during third trimester of pregnancy predicted postpartum symptoms of mania, depression, and obsessive-compulsive disorder (OCD). Fifty-one women with a previous, but not active, episode of unipolar or bipolar depression had symptoms evaluated and sleep recorded with wrist actigraphy at 33 weeks of gestation and 2, 6, and 16 weeks postpartum. Circadian phase was measured in a subset of women using salivary dim light melatonin onset (DLMO). We divided the sample into “early sleep” and “late sleep” groups using average sleep onset time at 33 weeks of gestation, defined by the median-split time of 11:27 p.m. The “late sleep” group reported significantly more manic and depressive symptoms at postpartum week 2. Longer phase angle between DLMO and sleep onset at 33 weeks was associated with more manic symptoms at postpartum week 2 and more obsessive-compulsive symptoms at week 6. Delayed sleep timing in this sample of at-risk women was associated with more symptoms of mania, depression, and OCD in the postpartum period. Sleep timing may be a modifiable risk factor for postpartum depression.
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spelling pubmed-70260622020-03-03 Delayed sleep timing and circadian rhythms in pregnancy and transdiagnostic symptoms associated with postpartum depression Obeysekare, Jessica L. Cohen, Zachary L. Coles, Meredith E. Pearlstein, Teri B. Monzon, Carmen Flynn, E. Ellen Sharkey, Katherine M. Transl Psychiatry Article Later sleep timing, circadian preference, and circadian rhythm timing predict worse outcomes across multiple domains, including mood disorders, substance use, impulse control, and cognitive function. Disturbed sleep is common among pregnant and postpartum women. We examined whether sleep timing during third trimester of pregnancy predicted postpartum symptoms of mania, depression, and obsessive-compulsive disorder (OCD). Fifty-one women with a previous, but not active, episode of unipolar or bipolar depression had symptoms evaluated and sleep recorded with wrist actigraphy at 33 weeks of gestation and 2, 6, and 16 weeks postpartum. Circadian phase was measured in a subset of women using salivary dim light melatonin onset (DLMO). We divided the sample into “early sleep” and “late sleep” groups using average sleep onset time at 33 weeks of gestation, defined by the median-split time of 11:27 p.m. The “late sleep” group reported significantly more manic and depressive symptoms at postpartum week 2. Longer phase angle between DLMO and sleep onset at 33 weeks was associated with more manic symptoms at postpartum week 2 and more obsessive-compulsive symptoms at week 6. Delayed sleep timing in this sample of at-risk women was associated with more symptoms of mania, depression, and OCD in the postpartum period. Sleep timing may be a modifiable risk factor for postpartum depression. Nature Publishing Group UK 2020-01-21 /pmc/articles/PMC7026062/ /pubmed/32066689 http://dx.doi.org/10.1038/s41398-020-0683-3 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Obeysekare, Jessica L.
Cohen, Zachary L.
Coles, Meredith E.
Pearlstein, Teri B.
Monzon, Carmen
Flynn, E. Ellen
Sharkey, Katherine M.
Delayed sleep timing and circadian rhythms in pregnancy and transdiagnostic symptoms associated with postpartum depression
title Delayed sleep timing and circadian rhythms in pregnancy and transdiagnostic symptoms associated with postpartum depression
title_full Delayed sleep timing and circadian rhythms in pregnancy and transdiagnostic symptoms associated with postpartum depression
title_fullStr Delayed sleep timing and circadian rhythms in pregnancy and transdiagnostic symptoms associated with postpartum depression
title_full_unstemmed Delayed sleep timing and circadian rhythms in pregnancy and transdiagnostic symptoms associated with postpartum depression
title_short Delayed sleep timing and circadian rhythms in pregnancy and transdiagnostic symptoms associated with postpartum depression
title_sort delayed sleep timing and circadian rhythms in pregnancy and transdiagnostic symptoms associated with postpartum depression
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7026062/
https://www.ncbi.nlm.nih.gov/pubmed/32066689
http://dx.doi.org/10.1038/s41398-020-0683-3
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