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Mechano-biological adaptation of the pulmonary artery exposed to systemic conditions

Cardiac surgeries may expose pulmonary arterial tissue to systemic conditions, potentially resulting in failure of that tissue. Our goal was to quantitatively assess pulmonary artery adaptation due to changes in mechanical environment. In 17 sheep, we placed a pulmonary autograft in aortic position,...

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Autores principales: Vanderveken, Emma, Vastmans, Julie, Claus, Piet, Verbeken, Eric, Fehervary, Heleen, Van Hoof, Lucas, Vandendriessche, Katrien, Verbrugghe, Peter, Famaey, Nele, Rega, Filip
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7026065/
https://www.ncbi.nlm.nih.gov/pubmed/32066803
http://dx.doi.org/10.1038/s41598-020-59554-7
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author Vanderveken, Emma
Vastmans, Julie
Claus, Piet
Verbeken, Eric
Fehervary, Heleen
Van Hoof, Lucas
Vandendriessche, Katrien
Verbrugghe, Peter
Famaey, Nele
Rega, Filip
author_facet Vanderveken, Emma
Vastmans, Julie
Claus, Piet
Verbeken, Eric
Fehervary, Heleen
Van Hoof, Lucas
Vandendriessche, Katrien
Verbrugghe, Peter
Famaey, Nele
Rega, Filip
author_sort Vanderveken, Emma
collection PubMed
description Cardiac surgeries may expose pulmonary arterial tissue to systemic conditions, potentially resulting in failure of that tissue. Our goal was to quantitatively assess pulmonary artery adaptation due to changes in mechanical environment. In 17 sheep, we placed a pulmonary autograft in aortic position, with or without macroporous mesh reinforcement. It was exposed to systemic conditions for 6 months. All sheep underwent 3 ECG-gated MRI’s. Explanted tissue was subjected to mechanical and histological analysis. Results showed progressive dilatation of the unreinforced autograft, while reinforced autografts stabilized after two months. Some unreinforced pulmonary autograft samples displayed more aorta-like mechanical behavior with increased collagen deposition. The mechanical behavior of reinforced autografts was dominated by the mesh. The decrease in media thickness and loss of vascular smooth muscle cells was more pronounced in reinforced than in unreinforced autografts. In conclusion, altering the mechanical environment of a pulmonary artery causes changes in its mechano-biological properties.
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spelling pubmed-70260652020-02-24 Mechano-biological adaptation of the pulmonary artery exposed to systemic conditions Vanderveken, Emma Vastmans, Julie Claus, Piet Verbeken, Eric Fehervary, Heleen Van Hoof, Lucas Vandendriessche, Katrien Verbrugghe, Peter Famaey, Nele Rega, Filip Sci Rep Article Cardiac surgeries may expose pulmonary arterial tissue to systemic conditions, potentially resulting in failure of that tissue. Our goal was to quantitatively assess pulmonary artery adaptation due to changes in mechanical environment. In 17 sheep, we placed a pulmonary autograft in aortic position, with or without macroporous mesh reinforcement. It was exposed to systemic conditions for 6 months. All sheep underwent 3 ECG-gated MRI’s. Explanted tissue was subjected to mechanical and histological analysis. Results showed progressive dilatation of the unreinforced autograft, while reinforced autografts stabilized after two months. Some unreinforced pulmonary autograft samples displayed more aorta-like mechanical behavior with increased collagen deposition. The mechanical behavior of reinforced autografts was dominated by the mesh. The decrease in media thickness and loss of vascular smooth muscle cells was more pronounced in reinforced than in unreinforced autografts. In conclusion, altering the mechanical environment of a pulmonary artery causes changes in its mechano-biological properties. Nature Publishing Group UK 2020-02-17 /pmc/articles/PMC7026065/ /pubmed/32066803 http://dx.doi.org/10.1038/s41598-020-59554-7 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Vanderveken, Emma
Vastmans, Julie
Claus, Piet
Verbeken, Eric
Fehervary, Heleen
Van Hoof, Lucas
Vandendriessche, Katrien
Verbrugghe, Peter
Famaey, Nele
Rega, Filip
Mechano-biological adaptation of the pulmonary artery exposed to systemic conditions
title Mechano-biological adaptation of the pulmonary artery exposed to systemic conditions
title_full Mechano-biological adaptation of the pulmonary artery exposed to systemic conditions
title_fullStr Mechano-biological adaptation of the pulmonary artery exposed to systemic conditions
title_full_unstemmed Mechano-biological adaptation of the pulmonary artery exposed to systemic conditions
title_short Mechano-biological adaptation of the pulmonary artery exposed to systemic conditions
title_sort mechano-biological adaptation of the pulmonary artery exposed to systemic conditions
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7026065/
https://www.ncbi.nlm.nih.gov/pubmed/32066803
http://dx.doi.org/10.1038/s41598-020-59554-7
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