How do bacterial membranes resist polymyxin antibiotics?

In our recent Communications Biology article, we reported on the biophysical mechanism of resistance for polymyxin antibiotics in bacterial membranes. The emergence of plasmid-borne colistin resistance poses a threat to our last line of defense against many pathogens. Here, we outline the current un...

Descripción completa

Detalles Bibliográficos
Autores principales: Khondker, Adree, Rheinstädter, Maikel C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Comment
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7026071/
https://www.ncbi.nlm.nih.gov/pubmed/32066819
http://dx.doi.org/10.1038/s42003-020-0803-x
_version_ 1783498613164343296
author Khondker, Adree
Rheinstädter, Maikel C.
author_facet Khondker, Adree
Rheinstädter, Maikel C.
author_sort Khondker, Adree
collection PubMed
description In our recent Communications Biology article, we reported on the biophysical mechanism of resistance for polymyxin antibiotics in bacterial membranes. The emergence of plasmid-borne colistin resistance poses a threat to our last line of defense against many pathogens. Here, we outline the current understanding of mcr-1-mediated polymyxin resistance, and propose future directions for membrane-targeting antibiotic research.
format Online
Article
Text
id pubmed-7026071
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Nature Publishing Group UK
record_format MEDLINE/PubMed
spelling pubmed-70260712020-03-03 How do bacterial membranes resist polymyxin antibiotics? Khondker, Adree Rheinstädter, Maikel C. Commun Biol Comment In our recent Communications Biology article, we reported on the biophysical mechanism of resistance for polymyxin antibiotics in bacterial membranes. The emergence of plasmid-borne colistin resistance poses a threat to our last line of defense against many pathogens. Here, we outline the current understanding of mcr-1-mediated polymyxin resistance, and propose future directions for membrane-targeting antibiotic research. Nature Publishing Group UK 2020-02-17 /pmc/articles/PMC7026071/ /pubmed/32066819 http://dx.doi.org/10.1038/s42003-020-0803-x Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Comment
Khondker, Adree
Rheinstädter, Maikel C.
How do bacterial membranes resist polymyxin antibiotics?
title How do bacterial membranes resist polymyxin antibiotics?
title_full How do bacterial membranes resist polymyxin antibiotics?
title_fullStr How do bacterial membranes resist polymyxin antibiotics?
title_full_unstemmed How do bacterial membranes resist polymyxin antibiotics?
title_short How do bacterial membranes resist polymyxin antibiotics?
title_sort how do bacterial membranes resist polymyxin antibiotics?
topic Comment
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7026071/
https://www.ncbi.nlm.nih.gov/pubmed/32066819
http://dx.doi.org/10.1038/s42003-020-0803-x
work_keys_str_mv AT khondkeradree howdobacterialmembranesresistpolymyxinantibiotics
AT rheinstadtermaikelc howdobacterialmembranesresistpolymyxinantibiotics

Ejemplares similares