Translational outcomes in a full gene deletion of ubiquitin protein ligase E3A rat model of Angelman syndrome

Angelman syndrome (AS) is a rare neurodevelopmental disorder characterized by developmental delay, impaired communication, motor deficits and ataxia, intellectual disabilities, microcephaly, and seizures. The genetic cause of AS is the loss of expression of UBE3A (ubiquitin protein ligase E6-AP) in...

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Autores principales: Berg, E. L., Pride, M. C., Petkova, S. P., Lee, R. D., Copping, N. A., Shen, Y., Adhikari, A., Fenton, T. A., Pedersen, L. R., Noakes, L. S., Nieman, B. J., Lerch, J. P., Harris, S., Born, H. A., Peters, M. M., Deng, P., Cameron, D. L., Fink, K. D., Beitnere, U., O’Geen, H., Anderson, A. E., Dindot, S. V., Nash, K. R., Weeber, E. J., Wöhr, M., Ellegood, J., Segal, D. J., Silverman, J. L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7026078/
https://www.ncbi.nlm.nih.gov/pubmed/32066685
http://dx.doi.org/10.1038/s41398-020-0720-2

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