A disinhibitory nigra-parafascicular pathway amplifies seizure in temporal lobe epilepsy

The precise circuit of the substantia nigra pars reticulata (SNr) involved in temporal lobe epilepsy (TLE) is still unclear. Here we found that optogenetic or chemogenetic activation of SNr parvalbumin(+) (PV) GABAergic neurons amplifies seizure activities in kindling- and kainic acid-induced TLE mo...

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Detalles Bibliográficos
Autores principales: Chen, Bin, Xu, Cenglin, Wang, Yi, Lin, Wenkai, Wang, Ying, Chen, Liying, Cheng, Heming, Xu, Lingyu, Hu, Tingting, Zhao, Junli, Dong, Ping, Guo, Yi, Zhang, Shihong, Wang, Shuang, Zhou, Yudong, Hu, Weiwei, Duan, Shuming, Chen, Zhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7026152/
https://www.ncbi.nlm.nih.gov/pubmed/32066723
http://dx.doi.org/10.1038/s41467-020-14648-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7026152/
https://www.ncbi.nlm.nih.gov/pubmed/32066723
http://dx.doi.org/10.1038/s41467-020-14648-8

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