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Kampō medicine and Muro disease (Amyotrophic Lateral Sclerosis and Parkinsonism-Dementia Complex)

Western Pacific Amyotrophic Lateral Sclerosis and Parkinsonism-dementia Complex (ALS/PDC) is a disappearing neurodegenerative disease in three former high-incidence foci of Guam-USA, Papua-Indonesia and Kii Peninsula, Honshu Island, Japan. The latter includes two distinct ALS/PDC-affected regions (H...

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Autores principales: Spencer, Peter S., Palmer, Valerie S., Kihira, Tameko, Yoshida, Sohei, Reis, Jacques, Yabushita, Momoko, Yase, Yoshiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7026288/
https://www.ncbi.nlm.nih.gov/pubmed/32090178
http://dx.doi.org/10.1016/j.ensci.2020.100230
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author Spencer, Peter S.
Palmer, Valerie S.
Kihira, Tameko
Yoshida, Sohei
Reis, Jacques
Yabushita, Momoko
Yase, Yoshiro
author_facet Spencer, Peter S.
Palmer, Valerie S.
Kihira, Tameko
Yoshida, Sohei
Reis, Jacques
Yabushita, Momoko
Yase, Yoshiro
author_sort Spencer, Peter S.
collection PubMed
description Western Pacific Amyotrophic Lateral Sclerosis and Parkinsonism-dementia Complex (ALS/PDC) is a disappearing neurodegenerative disease in three former high-incidence foci of Guam-USA, Papua-Indonesia and Kii Peninsula, Honshu Island, Japan. The latter includes two distinct ALS/PDC-affected regions (Hohara and Kozagawa), where the disorder is known as Muro disease. In Hohara, oral exposure to plant (cycad) neurotoxins used in traditional medical practice has been linked previously to Muro disease. We report new observations that link Kampō medicine to Muro disease in the southern Kozagawa focus. Oral exposure to cycad seed toxins is associated with all three foci of Western Pacific ALS/PDC.
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spelling pubmed-70262882020-02-21 Kampō medicine and Muro disease (Amyotrophic Lateral Sclerosis and Parkinsonism-Dementia Complex) Spencer, Peter S. Palmer, Valerie S. Kihira, Tameko Yoshida, Sohei Reis, Jacques Yabushita, Momoko Yase, Yoshiro eNeurologicalSci Letters to the Editor Western Pacific Amyotrophic Lateral Sclerosis and Parkinsonism-dementia Complex (ALS/PDC) is a disappearing neurodegenerative disease in three former high-incidence foci of Guam-USA, Papua-Indonesia and Kii Peninsula, Honshu Island, Japan. The latter includes two distinct ALS/PDC-affected regions (Hohara and Kozagawa), where the disorder is known as Muro disease. In Hohara, oral exposure to plant (cycad) neurotoxins used in traditional medical practice has been linked previously to Muro disease. We report new observations that link Kampō medicine to Muro disease in the southern Kozagawa focus. Oral exposure to cycad seed toxins is associated with all three foci of Western Pacific ALS/PDC. Elsevier 2020-02-11 /pmc/articles/PMC7026288/ /pubmed/32090178 http://dx.doi.org/10.1016/j.ensci.2020.100230 Text en © 2020 The Authors. Published by Elsevier B.V. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Letters to the Editor
Spencer, Peter S.
Palmer, Valerie S.
Kihira, Tameko
Yoshida, Sohei
Reis, Jacques
Yabushita, Momoko
Yase, Yoshiro
Kampō medicine and Muro disease (Amyotrophic Lateral Sclerosis and Parkinsonism-Dementia Complex)
title Kampō medicine and Muro disease (Amyotrophic Lateral Sclerosis and Parkinsonism-Dementia Complex)
title_full Kampō medicine and Muro disease (Amyotrophic Lateral Sclerosis and Parkinsonism-Dementia Complex)
title_fullStr Kampō medicine and Muro disease (Amyotrophic Lateral Sclerosis and Parkinsonism-Dementia Complex)
title_full_unstemmed Kampō medicine and Muro disease (Amyotrophic Lateral Sclerosis and Parkinsonism-Dementia Complex)
title_short Kampō medicine and Muro disease (Amyotrophic Lateral Sclerosis and Parkinsonism-Dementia Complex)
title_sort kampō medicine and muro disease (amyotrophic lateral sclerosis and parkinsonism-dementia complex)
topic Letters to the Editor
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7026288/
https://www.ncbi.nlm.nih.gov/pubmed/32090178
http://dx.doi.org/10.1016/j.ensci.2020.100230
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