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The effects of a multispecies synbiotic on microbiome-related side effects of long-term proton pump inhibitor use: A pilot study
Side effects of proton pump inhibitors (PPI) can be linked to the changes in the intestinal microbiome that occur during therapy, especially in long-term users. Therefore, the microbiome might also be a key player in the reduction of PPI side effects. We tested the effects of a three-month intervent...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Nature Publishing Group UK
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7026433/ https://www.ncbi.nlm.nih.gov/pubmed/32066847 http://dx.doi.org/10.1038/s41598-020-59550-x |
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author | Horvath, Angela Leber, Bettina Feldbacher, Nicole Steinwender, Markus Komarova, Irina Rainer, Florian Blesl, Andreas Stadlbauer, Vanessa |
author_facet | Horvath, Angela Leber, Bettina Feldbacher, Nicole Steinwender, Markus Komarova, Irina Rainer, Florian Blesl, Andreas Stadlbauer, Vanessa |
author_sort | Horvath, Angela |
collection | PubMed |
description | Side effects of proton pump inhibitors (PPI) can be linked to the changes in the intestinal microbiome that occur during therapy, especially in long-term users. Therefore, the microbiome might also be a key player in the reduction of PPI side effects. We tested the effects of a three-month intervention with a multispecies synbiotic on intestinal inflammation, gut barrier function, microbiome composition, routine laboratory parameters and quality of life in patients with long-term PPI therapy. Thirty-six patients received a daily dose of a multispecies synbiotic for three months and were clinically observed without intervention for another three months. After intervention 17% of patients reached normal calprotectin levels; the overall reduction did not reach statistical significance (−18.8 ng/mg; 95%CI: −50.5; 12.9, p = 0.2). Elevated zonulin levels could be significantly reduced (−46.3 ng/mg; 95%CI: −71.4; −21.2; p < 0.001). The abundance of Stomatobaculum in the microbiome was reduced and Bacillus increased during the intervention. Furthermore, albumin, alkaline phosphatase and thrombocyte count were significantly increased and aspartate transaminase was significantly decreased during intervention. Gastrointestinal quality of life showed significant improvements. In conclusion, microbiome-related side effects of long-term PPI use can be substantially reduced by synbiotic intervention. Further studies are warranted to optimize dosage and duration of the intervention. |
format | Online Article Text |
id | pubmed-7026433 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-70264332020-02-26 The effects of a multispecies synbiotic on microbiome-related side effects of long-term proton pump inhibitor use: A pilot study Horvath, Angela Leber, Bettina Feldbacher, Nicole Steinwender, Markus Komarova, Irina Rainer, Florian Blesl, Andreas Stadlbauer, Vanessa Sci Rep Article Side effects of proton pump inhibitors (PPI) can be linked to the changes in the intestinal microbiome that occur during therapy, especially in long-term users. Therefore, the microbiome might also be a key player in the reduction of PPI side effects. We tested the effects of a three-month intervention with a multispecies synbiotic on intestinal inflammation, gut barrier function, microbiome composition, routine laboratory parameters and quality of life in patients with long-term PPI therapy. Thirty-six patients received a daily dose of a multispecies synbiotic for three months and were clinically observed without intervention for another three months. After intervention 17% of patients reached normal calprotectin levels; the overall reduction did not reach statistical significance (−18.8 ng/mg; 95%CI: −50.5; 12.9, p = 0.2). Elevated zonulin levels could be significantly reduced (−46.3 ng/mg; 95%CI: −71.4; −21.2; p < 0.001). The abundance of Stomatobaculum in the microbiome was reduced and Bacillus increased during the intervention. Furthermore, albumin, alkaline phosphatase and thrombocyte count were significantly increased and aspartate transaminase was significantly decreased during intervention. Gastrointestinal quality of life showed significant improvements. In conclusion, microbiome-related side effects of long-term PPI use can be substantially reduced by synbiotic intervention. Further studies are warranted to optimize dosage and duration of the intervention. Nature Publishing Group UK 2020-02-17 /pmc/articles/PMC7026433/ /pubmed/32066847 http://dx.doi.org/10.1038/s41598-020-59550-x Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Horvath, Angela Leber, Bettina Feldbacher, Nicole Steinwender, Markus Komarova, Irina Rainer, Florian Blesl, Andreas Stadlbauer, Vanessa The effects of a multispecies synbiotic on microbiome-related side effects of long-term proton pump inhibitor use: A pilot study |
title | The effects of a multispecies synbiotic on microbiome-related side effects of long-term proton pump inhibitor use: A pilot study |
title_full | The effects of a multispecies synbiotic on microbiome-related side effects of long-term proton pump inhibitor use: A pilot study |
title_fullStr | The effects of a multispecies synbiotic on microbiome-related side effects of long-term proton pump inhibitor use: A pilot study |
title_full_unstemmed | The effects of a multispecies synbiotic on microbiome-related side effects of long-term proton pump inhibitor use: A pilot study |
title_short | The effects of a multispecies synbiotic on microbiome-related side effects of long-term proton pump inhibitor use: A pilot study |
title_sort | effects of a multispecies synbiotic on microbiome-related side effects of long-term proton pump inhibitor use: a pilot study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7026433/ https://www.ncbi.nlm.nih.gov/pubmed/32066847 http://dx.doi.org/10.1038/s41598-020-59550-x |
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