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Stereotaxic Diffusion Tensor Imaging White Matter Atlas for the in vivo Domestic Feline Brain

The cat brain is a useful model for neuroscientific research and with the increasing use of advanced neuroimaging techniques there is a need for an open-source stereotaxic white matter brain atlas to accompany the cortical gray matter atlas, currently available. A stereotaxic white matter atlas woul...

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Autores principales: Johnson, Philippa J., Pascalau, Raluca, Luh, Wen-Ming, Raj, Ashish, Cerda-Gonzalez, Sofia, Barry, Erica F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7026623/
https://www.ncbi.nlm.nih.gov/pubmed/32116572
http://dx.doi.org/10.3389/fnana.2020.00001
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author Johnson, Philippa J.
Pascalau, Raluca
Luh, Wen-Ming
Raj, Ashish
Cerda-Gonzalez, Sofia
Barry, Erica F.
author_facet Johnson, Philippa J.
Pascalau, Raluca
Luh, Wen-Ming
Raj, Ashish
Cerda-Gonzalez, Sofia
Barry, Erica F.
author_sort Johnson, Philippa J.
collection PubMed
description The cat brain is a useful model for neuroscientific research and with the increasing use of advanced neuroimaging techniques there is a need for an open-source stereotaxic white matter brain atlas to accompany the cortical gray matter atlas, currently available. A stereotaxic white matter atlas would facilitate anatomic registration and segmentation of the white matter to aid in lesion localization or standardized regional analysis of specific regions of the white matter. In this article, we document the creation of a stereotaxic feline white matter atlas from diffusion tensor imaging (DTI) data obtained from a population of eight mesaticephalic felines. Deterministic tractography reconstructions were performed to create tract priors for the major white matter projections of Corpus callosum (CC), fornix, cingulum, uncinate, Corona Radiata (CR), Corticospinal tract (CST), inferior longitudinal fasciculus (ILF), Superior Longitudinal Fasciculus (SLF), and the cerebellar tracts. T1-weighted, fractional anisotropy (FA), mean diffusivity (MD), radial diffusivity (RD) and axial diffusivity (AD) population maps were generated. The volume, mean tract length and mean FA, MD, AD and RD values for each tract prior were documented. A structural connectome was then created using previously published cortical priors and the connectivity metrics for all cortical regions documented. The provided white matter atlas, diffusivity maps, tract priors and connectome will be a valuable resource for anatomical, pathological and translational neuroimaging research in the feline model. Multi-atlas population maps and segmentation priors are available at Cornell’s digital repository: https://ecommons.cornell.edu/handle/1813/58775.2.
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spelling pubmed-70266232020-02-28 Stereotaxic Diffusion Tensor Imaging White Matter Atlas for the in vivo Domestic Feline Brain Johnson, Philippa J. Pascalau, Raluca Luh, Wen-Ming Raj, Ashish Cerda-Gonzalez, Sofia Barry, Erica F. Front Neuroanat Neuroscience The cat brain is a useful model for neuroscientific research and with the increasing use of advanced neuroimaging techniques there is a need for an open-source stereotaxic white matter brain atlas to accompany the cortical gray matter atlas, currently available. A stereotaxic white matter atlas would facilitate anatomic registration and segmentation of the white matter to aid in lesion localization or standardized regional analysis of specific regions of the white matter. In this article, we document the creation of a stereotaxic feline white matter atlas from diffusion tensor imaging (DTI) data obtained from a population of eight mesaticephalic felines. Deterministic tractography reconstructions were performed to create tract priors for the major white matter projections of Corpus callosum (CC), fornix, cingulum, uncinate, Corona Radiata (CR), Corticospinal tract (CST), inferior longitudinal fasciculus (ILF), Superior Longitudinal Fasciculus (SLF), and the cerebellar tracts. T1-weighted, fractional anisotropy (FA), mean diffusivity (MD), radial diffusivity (RD) and axial diffusivity (AD) population maps were generated. The volume, mean tract length and mean FA, MD, AD and RD values for each tract prior were documented. A structural connectome was then created using previously published cortical priors and the connectivity metrics for all cortical regions documented. The provided white matter atlas, diffusivity maps, tract priors and connectome will be a valuable resource for anatomical, pathological and translational neuroimaging research in the feline model. Multi-atlas population maps and segmentation priors are available at Cornell’s digital repository: https://ecommons.cornell.edu/handle/1813/58775.2. Frontiers Media S.A. 2020-02-11 /pmc/articles/PMC7026623/ /pubmed/32116572 http://dx.doi.org/10.3389/fnana.2020.00001 Text en Copyright © 2020 Johnson, Pascalau, Luh, Raj, Cerda-Gonzalez and Barry. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Johnson, Philippa J.
Pascalau, Raluca
Luh, Wen-Ming
Raj, Ashish
Cerda-Gonzalez, Sofia
Barry, Erica F.
Stereotaxic Diffusion Tensor Imaging White Matter Atlas for the in vivo Domestic Feline Brain
title Stereotaxic Diffusion Tensor Imaging White Matter Atlas for the in vivo Domestic Feline Brain
title_full Stereotaxic Diffusion Tensor Imaging White Matter Atlas for the in vivo Domestic Feline Brain
title_fullStr Stereotaxic Diffusion Tensor Imaging White Matter Atlas for the in vivo Domestic Feline Brain
title_full_unstemmed Stereotaxic Diffusion Tensor Imaging White Matter Atlas for the in vivo Domestic Feline Brain
title_short Stereotaxic Diffusion Tensor Imaging White Matter Atlas for the in vivo Domestic Feline Brain
title_sort stereotaxic diffusion tensor imaging white matter atlas for the in vivo domestic feline brain
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7026623/
https://www.ncbi.nlm.nih.gov/pubmed/32116572
http://dx.doi.org/10.3389/fnana.2020.00001
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