Cargando…

Deamination hotspots among APOBEC3 family members are defined by both target site sequence context and ssDNA secondary structure

The human apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3 (APOBEC3, A3) family member proteins can deaminate cytosines in single-strand (ss) DNA, which restricts human immunodeficiency virus type 1 (HIV-1), retrotransposons, and other viruses such as hepatitis B virus, but can cau...

Descripción completa

Detalles Bibliográficos
Autores principales: McDaniel, Yumeng Z, Wang, Dake, Love, Robin P, Adolph, Madison B, Mohammadzadeh, Nazanin, Chelico, Linda, Mansky, Louis M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7026630/
https://www.ncbi.nlm.nih.gov/pubmed/31943071
http://dx.doi.org/10.1093/nar/gkz1164