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Protect-seq: genome-wide profiling of nuclease inaccessible domains reveals physical properties of chromatin

In metazoan cell nuclei, heterochromatin constitutes large chromatin domains that are in close contact with the nuclear lamina. These heterochromatin/lamina-associated domains (LADs) domains are difficult to profile and warrants a simpler and direct method. Here we report a new method, Protect-seq,...

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Detalles Bibliográficos
Autores principales: Spracklin, George, Pradhan, Sriharsa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7026637/
https://www.ncbi.nlm.nih.gov/pubmed/31819993
http://dx.doi.org/10.1093/nar/gkz1150