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Secondary nucleotide messenger c-di-GMP exerts a global control on natural product biosynthesis in streptomycetes

Cyclic dimeric 3′-5′ guanosine monophosphate, c-di-GMP, is a ubiquitous second messenger controlling diverse cellular processes in bacteria. In streptomycetes, c-di-GMP plays a crucial role in a complex morphological differentiation by modulating an activity of the pleiotropic regulator BldD. Here w...

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Detalles Bibliográficos
Autores principales: Makitrynskyy, Roman, Tsypik, Olga, Nuzzo, Desirèe, Paululat, Thomas, Zechel, David L, Bechthold, Andreas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7026642/
https://www.ncbi.nlm.nih.gov/pubmed/31956908
http://dx.doi.org/10.1093/nar/gkz1220