Golgi-endosome transport mediated by M6PR facilitates release of antisense oligonucleotides from endosomes

Release of phosphorothioate antisense oligonucleotides (PS-ASOs) from late endosomes (LEs) is a rate-limiting step and a poorly defined process for productive intracellular ASO drug delivery. Here, we examined the role of Golgi-endosome transport, specifically M6PR shuttling mediated by GCC2, in PS-...

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Detalles Bibliográficos
Autores principales: Liang, Xue-hai, Sun, Hong, Hsu, Chih-Wei, Nichols, Joshua G, Vickers, Timothy A, De Hoyos, Cheryl L, Crooke, Stanley T
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7026651/
https://www.ncbi.nlm.nih.gov/pubmed/31840180
http://dx.doi.org/10.1093/nar/gkz1171

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7026651/
https://www.ncbi.nlm.nih.gov/pubmed/31840180
http://dx.doi.org/10.1093/nar/gkz1171

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