An R-loop-initiated CSB–RAD52–POLD3 pathway suppresses ROS-induced telomeric DNA breaks

Reactive oxygen species (ROS) inflict multiple types of lesions in DNA, threatening genomic integrity. How cells respond to ROS-induced DNA damage at telomeres is still largely unknown. Here, we show that ROS-induced DNA damage at telomeres triggers R-loop accumulation in a TERRA- and TRF2-dependent...

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Detalles Bibliográficos
Autores principales: Tan, Jun, Duan, Meihan, Yadav, Tribhuwan, Phoon, Laiyee, Wang, Xiangyu, Zhang, Jia-Min, Zou, Lee, Lan, Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7026659/
https://www.ncbi.nlm.nih.gov/pubmed/31777915
http://dx.doi.org/10.1093/nar/gkz1114

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