Indirect Impact of PD-1/PD-L1 Blockade on a Murine Model of NK Cell Exhaustion

The induction of exhaustion on effector immune cells is an important limiting factor for cancer immunotherapy efficacy as these cells undergo a hierarchical loss of proliferation and cytolytic activity due to chronic stimulation. Targeting PD-1 has shown unprecedented clinical benefits for many canc...

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Detalles Bibliográficos
Autores principales: Alvarez, Maite, Simonetta, Federico, Baker, Jeanette, Morrison, Alyssa R., Wenokur, Arielle S., Pierini, Antonio, Berraondo, Pedro, Negrin, Robert S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7026672/
https://www.ncbi.nlm.nih.gov/pubmed/32117218
http://dx.doi.org/10.3389/fimmu.2020.00007

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7026672/
https://www.ncbi.nlm.nih.gov/pubmed/32117218
http://dx.doi.org/10.3389/fimmu.2020.00007

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