NF-κB System Is Chronically Activated and Promotes Glomerular Injury in Experimental Type 1 Diabetic Kidney Disease

High glucose concentration can activate TLR4 and NF-κB, triggering the production of proinflammatory mediators. We investigated whether the NF-κB pathway is involved in the pathogenesis and progression of experimental diabetic kidney disease (DKD) in a model of long-term type 1 diabetes mellitus (DM...

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Detalles Bibliográficos
Autores principales: Foresto-Neto, Orestes, Albino, Amanda Helen, Arias, Simone Costa Alarcon, Faustino, Viviane Dias, Zambom, Fernanda Florencia Fregnan, Cenedeze, Marcos Antonio, Elias, Rosilene Motta, Malheiros, Denise Maria Avancini Costa, Camara, Niels Olsen Saraiva, Fujihara, Clarice Kazue, Zatz, Roberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7026681/
https://www.ncbi.nlm.nih.gov/pubmed/32116790
http://dx.doi.org/10.3389/fphys.2020.00084

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