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Exploring TOF capabilities of PET detector blocks based on large monolithic crystals and analog SiPMs

Monolithic scintillators are more frequently used in PET instrumentation due to their advantages in terms of accurate position estimation of the impinging gamma rays both planar and depth of interaction, their increased efficiency, and expected timing capabilities. Such timing performance has been s...

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Autores principales: Lamprou, Efthymios, Gonzalez, Antonio J., Sanchez, Filomeno, Benlloch, Jose M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Istituti Editoriali e Poligrafici Internazionali 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7026714/
https://www.ncbi.nlm.nih.gov/pubmed/31935602
http://dx.doi.org/10.1016/j.ejmp.2019.12.004
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author Lamprou, Efthymios
Gonzalez, Antonio J.
Sanchez, Filomeno
Benlloch, Jose M.
author_facet Lamprou, Efthymios
Gonzalez, Antonio J.
Sanchez, Filomeno
Benlloch, Jose M.
author_sort Lamprou, Efthymios
collection PubMed
description Monolithic scintillators are more frequently used in PET instrumentation due to their advantages in terms of accurate position estimation of the impinging gamma rays both planar and depth of interaction, their increased efficiency, and expected timing capabilities. Such timing performance has been studied when those blocks are coupled to digital photosensors showing an excellent timing resolution. In this work we study the timing behaviour of detectors composed by monolithic crystals and analog SiPMs read out by an ASIC. The scintillation light spreads across the crystal towards the photosensors, resulting in a high number of SiPMs and ASIC channels fired. This has been studied in relation with the Coincidence Timing Resolution (CTR). We have used LYSO monolithic blocks with dimensions of 50 × 50 × 15 mm(3) coupled to SiPM arrays (8 × 8 elements with 6 × 6 mm(2) area) which compose detectors suitable for clinical applications. While a CTR as good as 186 ps FWHM was achieved for a pair of 3 × 3 × 5 mm(3) LYSO crystals, when using the monolithic block and the SiPM arrays, a raw CTR over 1 ns was observed. An optimal timestamp assignment was studied as well as compensation methods for the time-skew and time-walk errors. This work describes all steps followed to improve the CTR. Eventually, an average detector time resolution of 497 ps FWHM was measured for the whole thick monolithic block. This improves to 380 ps FWHM for a central volume of interest near the photosensors. The timing dependency with the photon depth of interaction and planar position are also included.
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spelling pubmed-70267142020-02-24 Exploring TOF capabilities of PET detector blocks based on large monolithic crystals and analog SiPMs Lamprou, Efthymios Gonzalez, Antonio J. Sanchez, Filomeno Benlloch, Jose M. Phys Med Article Monolithic scintillators are more frequently used in PET instrumentation due to their advantages in terms of accurate position estimation of the impinging gamma rays both planar and depth of interaction, their increased efficiency, and expected timing capabilities. Such timing performance has been studied when those blocks are coupled to digital photosensors showing an excellent timing resolution. In this work we study the timing behaviour of detectors composed by monolithic crystals and analog SiPMs read out by an ASIC. The scintillation light spreads across the crystal towards the photosensors, resulting in a high number of SiPMs and ASIC channels fired. This has been studied in relation with the Coincidence Timing Resolution (CTR). We have used LYSO monolithic blocks with dimensions of 50 × 50 × 15 mm(3) coupled to SiPM arrays (8 × 8 elements with 6 × 6 mm(2) area) which compose detectors suitable for clinical applications. While a CTR as good as 186 ps FWHM was achieved for a pair of 3 × 3 × 5 mm(3) LYSO crystals, when using the monolithic block and the SiPM arrays, a raw CTR over 1 ns was observed. An optimal timestamp assignment was studied as well as compensation methods for the time-skew and time-walk errors. This work describes all steps followed to improve the CTR. Eventually, an average detector time resolution of 497 ps FWHM was measured for the whole thick monolithic block. This improves to 380 ps FWHM for a central volume of interest near the photosensors. The timing dependency with the photon depth of interaction and planar position are also included. Istituti Editoriali e Poligrafici Internazionali 2020-02 /pmc/articles/PMC7026714/ /pubmed/31935602 http://dx.doi.org/10.1016/j.ejmp.2019.12.004 Text en © 2020 Associazione Italiana di Fisica Medica. Published by Elsevier Ltd. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Lamprou, Efthymios
Gonzalez, Antonio J.
Sanchez, Filomeno
Benlloch, Jose M.
Exploring TOF capabilities of PET detector blocks based on large monolithic crystals and analog SiPMs
title Exploring TOF capabilities of PET detector blocks based on large monolithic crystals and analog SiPMs
title_full Exploring TOF capabilities of PET detector blocks based on large monolithic crystals and analog SiPMs
title_fullStr Exploring TOF capabilities of PET detector blocks based on large monolithic crystals and analog SiPMs
title_full_unstemmed Exploring TOF capabilities of PET detector blocks based on large monolithic crystals and analog SiPMs
title_short Exploring TOF capabilities of PET detector blocks based on large monolithic crystals and analog SiPMs
title_sort exploring tof capabilities of pet detector blocks based on large monolithic crystals and analog sipms
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7026714/
https://www.ncbi.nlm.nih.gov/pubmed/31935602
http://dx.doi.org/10.1016/j.ejmp.2019.12.004
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