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Acetic Acid-Induced Ulcerative Colitis in Sprague Dawley Rats Is Suppressed by Hydroethanolic Extract of Cordia vignei Leaves through Reduced Serum Levels of TNF-α and IL-6

BACKGROUND: Ulcerative colitis (UC) is a recurrent inflammatory bowel disease (IBD) that causes long-lasting inflammation on the innermost lining of the colon and rectum. Leaf decoctions of Cordia vignei have been used in traditional medicine either alone or in combination with other plant preparati...

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Autores principales: Owusu, George, Obiri, David D., Ainooson, George K., Osafo, Newman, Antwi, Aaron O., Duduyemi, Babatunde M., Ansah, Charles
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7026722/
https://www.ncbi.nlm.nih.gov/pubmed/32090060
http://dx.doi.org/10.1155/2020/8785497
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author Owusu, George
Obiri, David D.
Ainooson, George K.
Osafo, Newman
Antwi, Aaron O.
Duduyemi, Babatunde M.
Ansah, Charles
author_facet Owusu, George
Obiri, David D.
Ainooson, George K.
Osafo, Newman
Antwi, Aaron O.
Duduyemi, Babatunde M.
Ansah, Charles
author_sort Owusu, George
collection PubMed
description BACKGROUND: Ulcerative colitis (UC) is a recurrent inflammatory bowel disease (IBD) that causes long-lasting inflammation on the innermost lining of the colon and rectum. Leaf decoctions of Cordia vignei have been used in traditional medicine either alone or in combination with other plant preparations to treat the disease. AIM: In this study, we investigated the effect of hydroethanolic extract of Cordia vignei have been used in traditional medicine either alone or in combination with other plant preparations to treat the disease. METHOD: Male Sprague Dawley rats received oral treatment of either saline (10 ml/kg), sulfasalazine (500 mg/kg), or CVE (30-300 mg/kg) daily for 7 days. On day 4, colitis was induced by a single intrarectal administration of 500 μl of acetic acid (4% v/v/ RESULTS: CVE significantly (P < 0.05) prevented colonic ulceration and reduced the inflammatory score. Serum levels of TNF-α and IL-6 were significantly reduced. Depletion of superoxide dismutase (SOD) and catalase (CAT) activities by acetic acid was significantly inhibited while lipid peroxidation indexed as malondialdehyde (MDA) level in the colon was reduced. However, loss of body weight was not significantly affected by treatment with CVE. CONCLUSION: This data suggest that CVE has a potential antiulcerative effect.
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spelling pubmed-70267222020-02-21 Acetic Acid-Induced Ulcerative Colitis in Sprague Dawley Rats Is Suppressed by Hydroethanolic Extract of Cordia vignei Leaves through Reduced Serum Levels of TNF-α and IL-6 Owusu, George Obiri, David D. Ainooson, George K. Osafo, Newman Antwi, Aaron O. Duduyemi, Babatunde M. Ansah, Charles Int J Chronic Dis Research Article BACKGROUND: Ulcerative colitis (UC) is a recurrent inflammatory bowel disease (IBD) that causes long-lasting inflammation on the innermost lining of the colon and rectum. Leaf decoctions of Cordia vignei have been used in traditional medicine either alone or in combination with other plant preparations to treat the disease. AIM: In this study, we investigated the effect of hydroethanolic extract of Cordia vignei have been used in traditional medicine either alone or in combination with other plant preparations to treat the disease. METHOD: Male Sprague Dawley rats received oral treatment of either saline (10 ml/kg), sulfasalazine (500 mg/kg), or CVE (30-300 mg/kg) daily for 7 days. On day 4, colitis was induced by a single intrarectal administration of 500 μl of acetic acid (4% v/v/ RESULTS: CVE significantly (P < 0.05) prevented colonic ulceration and reduced the inflammatory score. Serum levels of TNF-α and IL-6 were significantly reduced. Depletion of superoxide dismutase (SOD) and catalase (CAT) activities by acetic acid was significantly inhibited while lipid peroxidation indexed as malondialdehyde (MDA) level in the colon was reduced. However, loss of body weight was not significantly affected by treatment with CVE. CONCLUSION: This data suggest that CVE has a potential antiulcerative effect. Hindawi 2020-02-06 /pmc/articles/PMC7026722/ /pubmed/32090060 http://dx.doi.org/10.1155/2020/8785497 Text en Copyright © 2020 George Owusu et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Owusu, George
Obiri, David D.
Ainooson, George K.
Osafo, Newman
Antwi, Aaron O.
Duduyemi, Babatunde M.
Ansah, Charles
Acetic Acid-Induced Ulcerative Colitis in Sprague Dawley Rats Is Suppressed by Hydroethanolic Extract of Cordia vignei Leaves through Reduced Serum Levels of TNF-α and IL-6
title Acetic Acid-Induced Ulcerative Colitis in Sprague Dawley Rats Is Suppressed by Hydroethanolic Extract of Cordia vignei Leaves through Reduced Serum Levels of TNF-α and IL-6
title_full Acetic Acid-Induced Ulcerative Colitis in Sprague Dawley Rats Is Suppressed by Hydroethanolic Extract of Cordia vignei Leaves through Reduced Serum Levels of TNF-α and IL-6
title_fullStr Acetic Acid-Induced Ulcerative Colitis in Sprague Dawley Rats Is Suppressed by Hydroethanolic Extract of Cordia vignei Leaves through Reduced Serum Levels of TNF-α and IL-6
title_full_unstemmed Acetic Acid-Induced Ulcerative Colitis in Sprague Dawley Rats Is Suppressed by Hydroethanolic Extract of Cordia vignei Leaves through Reduced Serum Levels of TNF-α and IL-6
title_short Acetic Acid-Induced Ulcerative Colitis in Sprague Dawley Rats Is Suppressed by Hydroethanolic Extract of Cordia vignei Leaves through Reduced Serum Levels of TNF-α and IL-6
title_sort acetic acid-induced ulcerative colitis in sprague dawley rats is suppressed by hydroethanolic extract of cordia vignei leaves through reduced serum levels of tnf-α and il-6
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7026722/
https://www.ncbi.nlm.nih.gov/pubmed/32090060
http://dx.doi.org/10.1155/2020/8785497
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