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PD-L1 and CD4 are independent prognostic factors for overall survival in endometrial carcinomas
BACKGROUND: Tumor microenvironment (TME) including the immune checkpoint system impacts prognosis in some types of malignancy. The aim of our study was to investigate the precise prognostic significance of the TME profile in endometrial carcinoma. METHODS: We performed immunohistochemistry of the TM...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7027009/ https://www.ncbi.nlm.nih.gov/pubmed/32066405 http://dx.doi.org/10.1186/s12885-020-6545-9 |
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author | Zhang, Shuang Minaguchi, Takeo Xu, Chenyang Qi, Nan Itagaki, Hiroya Shikama, Ayumi Tasaka, Nobutaka Akiyama, Azusa Sakurai, Manabu Ochi, Hiroyuki Satoh, Toyomi |
author_facet | Zhang, Shuang Minaguchi, Takeo Xu, Chenyang Qi, Nan Itagaki, Hiroya Shikama, Ayumi Tasaka, Nobutaka Akiyama, Azusa Sakurai, Manabu Ochi, Hiroyuki Satoh, Toyomi |
author_sort | Zhang, Shuang |
collection | PubMed |
description | BACKGROUND: Tumor microenvironment (TME) including the immune checkpoint system impacts prognosis in some types of malignancy. The aim of our study was to investigate the precise prognostic significance of the TME profile in endometrial carcinoma. METHODS: We performed immunohistochemistry of the TME proteins, PD-L1, PD-1, CD4, CD8, CD68, and VEGF in endometrial carcinomas from 221 patients. RESULTS: High PD-L1 in tumor cells (TCs) was associated with better OS (p = 0.004), whereas high PD-L1 in tumor-infiltrating immune cells (TICs) was associated with worse OS (p = 0.02). High PD-L1 in TICs correlated with high densities of CD8(+) TICs and CD68(+) TICs, as well as microsatellite instability (p = 0.00000064, 0.00078, and 0.0056), while high PD-L1 in TCs correlated with longer treatment-free interval (TFI) after primary chemotherapy in recurrent cases (p = 0.000043). High density of CD4(+) TICs correlated with better OS and longer TFI (p = 0.0008 and 0.014). Univariate and multivariate analyses of prognostic factors revealed that high PD-L1 in TCs and high density of CD4(+) TICs were significant and independent for favorable OS (p = 0.014 and 0.0025). CONCLUSION: The current findings indicate that PD-L1 and CD4(+) helper T cells may be reasonable targets for improving survival through manipulating chemosensitivity, providing significant implications for combining immunotherapies into the therapeutic strategy for endometrial carcinoma. |
format | Online Article Text |
id | pubmed-7027009 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-70270092020-02-24 PD-L1 and CD4 are independent prognostic factors for overall survival in endometrial carcinomas Zhang, Shuang Minaguchi, Takeo Xu, Chenyang Qi, Nan Itagaki, Hiroya Shikama, Ayumi Tasaka, Nobutaka Akiyama, Azusa Sakurai, Manabu Ochi, Hiroyuki Satoh, Toyomi BMC Cancer Research Article BACKGROUND: Tumor microenvironment (TME) including the immune checkpoint system impacts prognosis in some types of malignancy. The aim of our study was to investigate the precise prognostic significance of the TME profile in endometrial carcinoma. METHODS: We performed immunohistochemistry of the TME proteins, PD-L1, PD-1, CD4, CD8, CD68, and VEGF in endometrial carcinomas from 221 patients. RESULTS: High PD-L1 in tumor cells (TCs) was associated with better OS (p = 0.004), whereas high PD-L1 in tumor-infiltrating immune cells (TICs) was associated with worse OS (p = 0.02). High PD-L1 in TICs correlated with high densities of CD8(+) TICs and CD68(+) TICs, as well as microsatellite instability (p = 0.00000064, 0.00078, and 0.0056), while high PD-L1 in TCs correlated with longer treatment-free interval (TFI) after primary chemotherapy in recurrent cases (p = 0.000043). High density of CD4(+) TICs correlated with better OS and longer TFI (p = 0.0008 and 0.014). Univariate and multivariate analyses of prognostic factors revealed that high PD-L1 in TCs and high density of CD4(+) TICs were significant and independent for favorable OS (p = 0.014 and 0.0025). CONCLUSION: The current findings indicate that PD-L1 and CD4(+) helper T cells may be reasonable targets for improving survival through manipulating chemosensitivity, providing significant implications for combining immunotherapies into the therapeutic strategy for endometrial carcinoma. BioMed Central 2020-02-17 /pmc/articles/PMC7027009/ /pubmed/32066405 http://dx.doi.org/10.1186/s12885-020-6545-9 Text en © The Author(s). 2020 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Article Zhang, Shuang Minaguchi, Takeo Xu, Chenyang Qi, Nan Itagaki, Hiroya Shikama, Ayumi Tasaka, Nobutaka Akiyama, Azusa Sakurai, Manabu Ochi, Hiroyuki Satoh, Toyomi PD-L1 and CD4 are independent prognostic factors for overall survival in endometrial carcinomas |
title | PD-L1 and CD4 are independent prognostic factors for overall survival in endometrial carcinomas |
title_full | PD-L1 and CD4 are independent prognostic factors for overall survival in endometrial carcinomas |
title_fullStr | PD-L1 and CD4 are independent prognostic factors for overall survival in endometrial carcinomas |
title_full_unstemmed | PD-L1 and CD4 are independent prognostic factors for overall survival in endometrial carcinomas |
title_short | PD-L1 and CD4 are independent prognostic factors for overall survival in endometrial carcinomas |
title_sort | pd-l1 and cd4 are independent prognostic factors for overall survival in endometrial carcinomas |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7027009/ https://www.ncbi.nlm.nih.gov/pubmed/32066405 http://dx.doi.org/10.1186/s12885-020-6545-9 |
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