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Metabolomic analyses of the bio-corona formed on TiO(2) nanoparticles incubated with plant leaf tissues

BACKGROUND: The surface of a nanoparticle adsorbs molecules from its surroundings with a specific affinity determined by the chemical and physical properties of the nanomaterial. When a nanoparticle is exposed to a biological system, the adsorbed molecules form a dynamic and specific surface layer c...

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Autores principales: Kurepa, Jasmina, Shull, Timothy E., Smalle, Jan A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7027069/
https://www.ncbi.nlm.nih.gov/pubmed/32066442
http://dx.doi.org/10.1186/s12951-020-00592-8
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author Kurepa, Jasmina
Shull, Timothy E.
Smalle, Jan A.
author_facet Kurepa, Jasmina
Shull, Timothy E.
Smalle, Jan A.
author_sort Kurepa, Jasmina
collection PubMed
description BACKGROUND: The surface of a nanoparticle adsorbs molecules from its surroundings with a specific affinity determined by the chemical and physical properties of the nanomaterial. When a nanoparticle is exposed to a biological system, the adsorbed molecules form a dynamic and specific surface layer called a bio-corona. The present study aimed to identify the metabolites that form the bio-corona around anatase TiO(2) nanoparticles incubated with leaves of the model plant Arabidopsis thaliana. RESULTS: We used an untargeted metabolomics approach and compared the metabolites isolated from wild-type plants with plants deficient in a class of polyphenolic compounds called flavonoids. CONCLUSIONS: These analyses showed that TiO(2) nanoparticle coronas are enriched for flavonoids and lipids and that these metabolite classes compete with each other for binding the nanoparticle surface.
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spelling pubmed-70270692020-02-24 Metabolomic analyses of the bio-corona formed on TiO(2) nanoparticles incubated with plant leaf tissues Kurepa, Jasmina Shull, Timothy E. Smalle, Jan A. J Nanobiotechnology Research BACKGROUND: The surface of a nanoparticle adsorbs molecules from its surroundings with a specific affinity determined by the chemical and physical properties of the nanomaterial. When a nanoparticle is exposed to a biological system, the adsorbed molecules form a dynamic and specific surface layer called a bio-corona. The present study aimed to identify the metabolites that form the bio-corona around anatase TiO(2) nanoparticles incubated with leaves of the model plant Arabidopsis thaliana. RESULTS: We used an untargeted metabolomics approach and compared the metabolites isolated from wild-type plants with plants deficient in a class of polyphenolic compounds called flavonoids. CONCLUSIONS: These analyses showed that TiO(2) nanoparticle coronas are enriched for flavonoids and lipids and that these metabolite classes compete with each other for binding the nanoparticle surface. BioMed Central 2020-02-17 /pmc/articles/PMC7027069/ /pubmed/32066442 http://dx.doi.org/10.1186/s12951-020-00592-8 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Kurepa, Jasmina
Shull, Timothy E.
Smalle, Jan A.
Metabolomic analyses of the bio-corona formed on TiO(2) nanoparticles incubated with plant leaf tissues
title Metabolomic analyses of the bio-corona formed on TiO(2) nanoparticles incubated with plant leaf tissues
title_full Metabolomic analyses of the bio-corona formed on TiO(2) nanoparticles incubated with plant leaf tissues
title_fullStr Metabolomic analyses of the bio-corona formed on TiO(2) nanoparticles incubated with plant leaf tissues
title_full_unstemmed Metabolomic analyses of the bio-corona formed on TiO(2) nanoparticles incubated with plant leaf tissues
title_short Metabolomic analyses of the bio-corona formed on TiO(2) nanoparticles incubated with plant leaf tissues
title_sort metabolomic analyses of the bio-corona formed on tio(2) nanoparticles incubated with plant leaf tissues
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7027069/
https://www.ncbi.nlm.nih.gov/pubmed/32066442
http://dx.doi.org/10.1186/s12951-020-00592-8
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AT smallejana metabolomicanalysesofthebiocoronaformedontio2nanoparticlesincubatedwithplantleaftissues